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Systemic mastocytosis
MONDO:0016586Systemic mastocytosis (SM) comprises a heterogeneous group of rare acquired and chronic hematological malignancies that are related to an abnormal proliferation of mast cells in tissue, including bone marrow, with or without skin involvement.
Also known as: Mast cell disease, systemic mastocytosis, systemic tissue Mast cell disease, systemic tissue mast cell disease, Aggressive systemic mastocytosis, SM, systemic mast cell disease, systemic mastocytosis with associated hemotologic non-mast cell lineage disease (SM-AHNMD)
1874 clinical trials for this condition and its sub-types, 11 tagged with Systemic mastocytosis itself.
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Sub-types of Systemic mastocytosis
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Mast cell leukemia 9 trials
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Indolent systemic mastocytosis 8 trials
2 sub-types
- Smouldering systemic mastocytosis 3 trials
- Isolated bone marrow mastocytosis 2 trials
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Aggressive systemic mastocytosis 4 trials
1 sub-type
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Extracutaneous mastocytoma 0 trials
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New hope for tough blood cancers: experimental drug MGD024 enters human testing
Disease control OngoingThis early-stage study tests a new drug called MGD024 in people with certain blood cancers (like leukemia and lymphoma) that came back or didn't get better with standard treatments. The main goal is to find the safest dose and watch for side effects. About 130 adults will receive…
Phase 1 • Sponsor: MacroGenics • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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New drug aims to ease daily misery of rare mast cell disease
Symptom relief OngoingThis phase 2 study tests whether the experimental drug bezuclastinib can reduce symptoms like itching, flushing, and fatigue in people with nonadvanced systemic mastocytosis, a rare condition where too many mast cells cause chronic discomfort. About 237 adults whose symptoms are …
Phase 2 • Sponsor: Cogent Biosciences, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC