Spinal cord disorder

Researchers are testing an experimental human monoclonal antibody called NG004 in people who have recently sustained an acute incomplete cervical spinal cord injury. Participants receive repeated injections of NG004 directly into the spinal fluid. The trial's main goal is to chec…

This study tests whether exercise using electrical stimulation can improve muscle strength and endurance in people with lower limb paralysis from conditions like spinal cord injury, stroke, or multiple sclerosis. Participants will use devices that send electrical signals to their…

This study combines two treatments—laser heat to destroy tumors near the spinal cord and precise radiation—to better control spine tumors that have spread from other cancers. About 60 adults with solid tumors will receive both therapies. The goal is to improve tumor control, redu…

This early study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and doable for people with chronic spinal cord injury. Six adults will try the 20-minute exercise sessions over 6 weeks. The goal is to see if this approach can be us…

This study is collecting real-world data on the Synergy Disc, an artificial disc implant for people with degenerative cervical disc disease. Researchers will follow 200 patients who have already received or will receive the implant, measuring pain and disability improvements over…

This study compares two FDA-approved artificial disc implants used in neck surgery for conditions like herniated discs or arthritis. Twenty adults aged 18 to 60 will be randomly assigned to receive either the Biomet Zimmer Mobi-C or Nuvasive Simplify implant. Researchers will mea…

This study is following 50 people who have or will receive the Synergy Disc, an artificial disc for the neck, to treat pain from degenerative disc disease. Researchers are measuring pain levels and neck function over 12 months, and checking for any device-related problems. The go…

This study tests a mobile health app called iMHere 2.0 designed to help veterans with spinal cord injury and their family caregivers manage stress and improve well-being. Researchers will work with 100 participants to gather feedback and tailor the app to their needs. The goal is…

This study tests whether an 8-week virtual program of yogic breathing and meditation can improve breathing, fatigue, emotional well-being, and quality of life in adults with spinal cord disorders. Participants attend two coach-guided sessions per week via Zoom and complete questi…

This study tests whether a spinal cord stimulator, combined with physical therapy, can help people who have had a stroke regain arm and hand movement. Twenty adults with long-term arm weakness will first do therapy alone, then get a spinal implant and repeat therapy with stimulat…

This study tests whether a mild electrical clip on the ear (called vagus nerve stimulation) can help people recover better after spine surgery for a condition called cervical myelopathy. The trial will include 36 adults with moderate to severe myelopathy who are scheduled for dec…

This study tests a new multi-speed ergonomic wheelchair designed to reduce shoulder overuse injuries common in manual wheelchair users. Thirty adults who use a manual wheelchair daily will try different gear ratios on various surfaces. The goal is to see if the design improves pr…

This study tests a new way to give radiation to people with cancer that has spread to the spine and is pressing on the spinal cord. The goal is to see if giving a slightly higher dose of radiation to the tumor while protecting the spinal cord is safe. About 60 adults with this co…

This study tests whether playing a virtual reality walking game at home can reduce neuropathic pain in adults with incomplete spinal cord injury. Participants will use a headset to see virtual legs and walk in a virtual world for about 30 minutes twice daily over 10 days. The goa…

This study tests whether gentle electrical stimulation on the back can help stabilize blood pressure in people who recently had a spinal cord injury. Participants will undergo sit-up tests with and without stimulation to see if it prevents dizziness and keeps blood pressure in a …

This study tests whether mild electrical stimulation on the back can help stabilize blood pressure in people with chronic spinal cord injury who experience dizziness or fainting when sitting up. Five participants will have their blood pressure measured while tilted on a table, wi…

This study looks at whether people with long-term spinal cord injury who also have a condition called autonomic dysreflexia (sudden high blood pressure) have changes in their heart structure. Researchers will use MRI scans to compare two groups: 24 people with high-level injury a…

This study looks at how stroke changes the way the spinal cord handles sensory signals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses in 15 people (some with stroke, some healthy). The goal is to better understand spinal …

This study looks at whether training physical and occupational therapists in motivational interviewing (a supportive communication style) helps people with spinal cord injuries or disorders engage more actively in their rehab sessions. About 180 patients will take part across thr…

This study explores how electrical stimulation of the spinal cord can help people with cervical spinal cord injury regain arm and hand function. Researchers will place electrodes on the spinal cord during surgery and test different stimulation patterns. The goal is to find the be…