Semantic dementia
MONDO:0010857Semantic dementia (SD) is a form of frontotemporal dementia (FTD), characterized by the progressive, amodal and profound loss of semantic knowledge (combination of visual associative agnosia, anomia, surface dyslexia or dysgraphia and disrupted comprehension of word meaning) and behavioral abnormalities, attributable to the degeneration of the anterior temporal lobes.
Also known as: dementia, frontotemporal, dementia, frontotemporal, with or without parkinsonism, semantic primary progressive aphasia, semantic variant PPA, FTD, Ftdp17, Ftld with Tau inclusions, Pallidopontonigral Degeneration
48 clinical trials for this condition and its sub-types, 32 tagged with Semantic dementia itself.
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Browse by category →Sub-types of Semantic dementia
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Experimental antibody aims to repair brain connections in rare dementia
Disease control Not yet recruitingThis study tests a new drug called NS101 in 15 people with semantic variant primary progressive aphasia (svPPA), a rare type of frontotemporal dementia that affects language and memory. The drug is an antibody designed to help repair connections between brain cells. The main goal…
Phase 2 • Sponsor: Hee-Jin Kim • Aim: Disease control
Last updated Jun 26, 2026 14:05 UTC
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New brain test aims to unravel language confusion in dementia
Diagnosis Not yet recruitingThis study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…
Sponsor: Hospices Civils de Lyon • Aim: Diagnosis
Last updated Jun 27, 2026 12:30 UTC
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Smart sensors could revolutionize dementia monitoring at home
Knowledge-focused Not yet recruitingThis study will test if wearable sensors can effectively monitor symptoms and daily function in people with frontotemporal dementia (FTD). Sixty adults with FTD will wear pendant and wrist sensors for two weeks at a time, every six months over two years. The goal is to develop di…
Sponsor: BioSensics • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Smart sensors could revolutionize how we track FTD symptoms
Knowledge-focused Not yet recruitingThis study tests whether wearable sensors and computerized voice and thinking tests can reliably track symptoms in people with frontotemporal dementia (FTD). Twenty participants will wear sensors and complete assessments at home over 12 months. The goal is to develop digital biom…
Sponsor: BioSensics • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC