Semantic dementia
MONDO:0010857Semantic dementia (SD) is a form of frontotemporal dementia (FTD), characterized by the progressive, amodal and profound loss of semantic knowledge (combination of visual associative agnosia, anomia, surface dyslexia or dysgraphia and disrupted comprehension of word meaning) and behavioral abnormalities, attributable to the degeneration of the anterior temporal lobes.
Also known as: dementia, frontotemporal, dementia, frontotemporal, with or without parkinsonism, semantic primary progressive aphasia, semantic variant PPA, FTD, Ftdp17, Ftld with Tau inclusions, Pallidopontonigral Degeneration
48 clinical trials for this condition and its sub-types, 32 tagged with Semantic dementia itself.
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Browse by category →Sub-types of Semantic dementia
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Can magnetic pulses to the brain boost speech in aphasia?
Symptom relief CompletedThis study tested whether repeated sessions of transcranial magnetic stimulation (TMS) could improve language in people with primary progressive aphasia (PPA), a condition that slowly damages language areas of the brain. Ten participants received both real and sham (fake) TMS ove…
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:02 UTC
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Gentle zaps to the brain may ease language loss in dementia
Symptom relief CompletedThis study tested whether a gentle, non-invasive brain stimulation technique called tDCS, combined with language therapy, could improve speech in 23 people with primary progressive aphasia (PPA). Participants received either real or fake (sham) stimulation daily for 10 days. Rese…
Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Scientists probe hidden memory system that might survive brain damage
Knowledge-focused CompletedThis completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…
Sponsor: Rennes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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What’s it like to live with bvFTD? researchers ask patients directly
Knowledge-focused CompletedThis study interviewed 26 adults who either have behavioral variant frontotemporal dementia (bvFTD) or carry a gene that puts them at risk. The goal was to learn how the condition affects daily life, emotions, and coping. No treatment or medication was tested—just listening and g…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Swallowing struggles in dementia add to caregiver burden, new study finds
Knowledge-focused CompletedThis study surveyed 219 family caregivers of people with dementia to explore how swallowing problems (dysphagia) affect their burden and needs. Caregivers completed a one-time online questionnaire about their experiences, stress, and knowledge. The goal is to better understand an…
Sponsor: University of Oregon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC