Reflex epilepsy

This study tests an oral drug, AV078, in people aged 12 and older with tuberous sclerosis complex (TSC) whose seizures are not controlled by standard medications. Participants are randomly assigned to receive AV078 or a placebo for 12 weeks. The goal is to see if AV078 safely red…

This study tests a liquid form of the seizure drug zonisamide in children aged 1 month to 17 years who have partial-onset seizures. The goal is to find the right dose and check for side effects. About 40 children will take the medicine for up to 12 weeks, with a follow-up visit o…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…

This study tests whether levetiracetam, a seizure medication, works as well as magnesium sulfate to prevent seizures in pregnant people with severe preeclampsia. About 1,240 participants at 32 weeks or more will be randomly assigned to one of the two drugs. The goal is to see if …

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers will compare 4 nights of real stimulation to 4 nights of sham (fake) stimulation in up to 16 patients. The goal is to see if better sleep ca…

This study will test whether using virtual reality headsets raises the risk of seizures in adolescents and adults with epilepsy. Forty participants will wear a VR headset while their brain activity is recorded with EEG, comparing periods with the display off, on, and with hand co…

This early-phase study tests whether the drug Cobenfy KarXT can change brain activity linked to memory in 50 adults with epilepsy who are already scheduled for brain surgery. Participants will take either the drug or a placebo on separate days and perform memory tasks while their…

This study will follow 200 children with epilepsy to find clues—like brain scans or EEG patterns—that show which kids are likely to become resistant to standard seizure medications. The goal is to catch these cases early and consider alternative treatments such as a ketogenic die…

This study will track 139 newborns who have seizures in their first month of life to learn how common these seizures are, what causes them, and how the babies fare during their hospital stay. Researchers will use exams, blood tests, and brain scans to gather information. The goal…