Recurrent respiratory papillomatosis
MONDO:0018955Recurrent respiratory papillomatosis is a rare respiratory disease characterized by the development of exophytic papillomas, affecting the mucosa of the upper aero-digestive tract (with a strong predilection for the larynx), caused by an infection with human papilloma virus. Symptoms at presentation may include hoarseness, chronic cough, dyspnea, recurrent upper respiratory infections, pneumonia, dysphagia, stridor, and/or failure to thrive.
Also known as: RRP, recurrent respiratory papillomatosis, AORRP (type), JORRP (type), adult-onset recurrent respiratory papillomatosis (type), juvenile laryngeal papilloma, juvenile-onset recurrent respiratory papillomatosis (type), laryngeal papilloma, recurrent
1448 clinical trials for this condition and its sub-types, 8 tagged with Recurrent respiratory papillomatosis itself.
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Sub-types of Recurrent respiratory papillomatosis
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Laryngeal papillomatosis 1 trial
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Immune drug shows promise against rare HPV throat tumors
Disease control CompletedThis study tested the drug pembrolizumab in 21 people with recurrent respiratory papillomatosis (RRP), a rare condition where HPV causes non-cancerous growths in the throat, windpipe, or lungs. The goal was to see if the drug could shrink these growths and reduce the need for fre…
Phase 2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:26 UTC
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DNA vaccine shows promise in cutting surgeries for rare throat tumor disease
Disease control CompletedThis study tested a new DNA vaccine called INO-3107 in 32 adults and children with recurrent respiratory papillomatosis (RRP), a rare condition where non-cancerous tumors grow in the airway due to HPV-6 or HPV-11. The vaccine was given with a device that uses electrical pulses to…
Phase 1/2 • Sponsor: Inovio Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC