DNA vaccine shows promise in cutting surgeries for rare throat tumor disease
NCT ID NCT04398433
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a new DNA vaccine called INO-3107 in 32 adults and children with recurrent respiratory papillomatosis (RRP), a rare condition where non-cancerous tumors grow in the airway due to HPV-6 or HPV-11. The vaccine was given with a device that uses electrical pulses to help it enter cells. The main goals were to check safety and see if it could reduce the number of surgeries needed to remove tumors. Participants were followed for a year after treatment to compare surgery rates to the year before.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor College of Medicine
Houston, Texas, 77005, United States
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Cincinnati Children's Hospital
Cincinnati, Ohio, 45229, United States
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Johns Hopkins University School of Medicine
Baltimore, Maryland, 21287, United States
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Mayo Clinic Arizona
Phoenix, Arizona, 85054, United States
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NYU Langone Voice Center
New York, New York, 10016, United States
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UNC School of Medicine
Chapel Hill, North Carolina, 27599, United States
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UT Southwestern Medical Center
Dallas, Texas, 75390, United States
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University of California at Davis
Sacramento, California, 95817, United States
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University of Cincinnati Medical Center
Cincinnati, Ohio, 45267, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Winship at Emory University Hospital Midtown
Atlanta, Georgia, 30308, United States