RASopathy

MONDO:0021060

Developmental syndromes caused by germline mutations (or in rare cases by somatic mosaicism) in genes that alter the Ras subfamily and mitogen-activated protein kinases that control signal transduction.

Also known as: RASopathy, Ras protein signal transduction disease, disorder of Ras protein signal transduction

98 clinical trials for this condition and its sub-types.

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Sub-types

Neurofibromatosis type 1 (72) Noonan syndrome (20) Cardiofaciocutaneous syndrome (6) Costello syndrome (6) Legius syndrome (5) Noonan syndrome with multiple lentigines (3) Neurofibromatosis-Noonan syndrome (2) Noonan syndrome 3 (2) Cardiofaciocutaneous syndrome 1 (1) CBL-related disorder (1) Noonan syndrome 5 (1) Cardiofaciocutaneous syndrome 2 (0) Cardiofaciocutaneous syndrome 3 (0) Cardiofaciocutaneous syndrome 4 (0) Chromosome 17q11.2 deletion syndrome, 1.4Mb (0) LEOPARD syndrome 1 (0) LEOPARD syndrome 2 (0) LEOPARD syndrome 3 (0) Neurofibromatosis, familial spinal (0) Neurofibromatosis type 1 due to NF1 mutation or intragenic deletion (0)

Broader categories

Disease (680) Hereditary disease (176) Human disease (14) Disease by molecular mechanism (2) Disease of genetic or genomic mechanism (2) Disease by developmental or physiological process (0) Disease by etiologic mechanism (0)

Trials to join now! 35 Not yet recruiting 7 Not yet finished but already full! 33 Completed 18 Terminated 5

RASopathy

Sub-types

Broader categories

Light-Activated cream could slow growth of NF1 skin tumors

New cancer pill shows early promise, but trial halted

Real-World study tracks Selumetinib's impact on NF1 tumors in children

Experimental cancer drug study halted early

Scientists dive into cells to unravel costello Syndrome's secrets