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Rapidly progressive glomerulonephritis

MONDO:0017236

Inflammation of the glomeruli that is characterized by a rapid loss in renal function with glomerular crescent formation observed on biopsy; it is often seen in patients with concomitant autoimmune disease, like Goodpasture's syndrome or systemic lupus erythematosus.

Also known as: RPGN, crescentic glomerulonephritis

7 clinical trials for this condition and its sub-types, 3 tagged with Rapidly progressive glomerulonephritis itself.

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Where it sits in the disease tree

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↑ Glomerulonephritis (457)

Sub-types of Rapidly progressive glomerulonephritis

Chronic rapidly progressive glomerulonephritis 1 trial

Including sub-types (7) Tagged with Rapidly progressive glomerulonephritis (3)

Trials to join now! 2 Not yet recruiting 1

New drug combo aims to save kidneys in rare autoimmune disease

Disease control Not yet recruiting

This Phase 3 trial tests whether adding avacopan to standard treatment helps people with severe ANCA vasculitis and serious kidney damage. About 130 participants will receive either avacopan or a placebo alongside usual care. The goal is to see if more patients recover kidney fun…

Phase 3 • Sponsor: University Hospital, Toulouse • Aim: Disease control

Last updated Jun 27, 2026 09:00 UTC

Rapidly progressive glomerulonephritis

Where it sits in the disease tree

New drug combo aims to save kidneys in rare autoimmune disease