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Pure autonomic failure

MONDO:0018608

Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension.

Also known as: Bradbury Eggleston syndrome, Bradbury-Eggleston syndrome, PAF, Pure dysautonomia, Pure idiopatic dysautonomia, idiopathic orthostatic hypotension, idiopathic orthostatic hypotension (a symptom), orthostatic hypotension (a symptom)

30 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Metabolic disease (233) Nervous system disorder (231) Neurodegenerative disease (171) Peripheral nervous system disorder (114) Central nervous system disorder (107) Multiple system atrophy (102) Movement disorder (98) Autonomic nervous system disorder (57) Human disease (14)
Trials to join now! 21 Not yet finished but already full! 1 Completed 7 Terminated 1
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  • Scientists probe hidden danger of low blood sugar in diabetes

    Knowledge-focused Terminated

    This study looked at why people with type 1 diabetes often fail to sense dangerously low blood sugar (hypoglycemia). Researchers tested how opioid drugs like morphine and naloxone affect the body's ability to respond to low sugar. The goal was to better understand the problem, no…

    Phase: PHASE2 • Sponsor: Albert Einstein College of Medicine • Aim: Knowledge-focused

    Last updated Jun 27, 2026 12:35 UTC

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