Pulmonary alveolar proteinosis
MONDO:0001437A rare lung disorder characterized by the filling of the pulmonary alveoli with proteinaceous material which stains positive with periodic acid-Schiff stain. It may be idiopathic or secondary due to hematologic malignancies or the inhalation of mineral dusts. Signs and symptoms include dyspnea, cough and low grade fever.
Also known as: PAP, pulmonary alveolar proteinosis
13 clinical trials for this condition and its sub-types.
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Broader categories
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Can a daily inhaled protein restore lung function in a rare autoimmune disease?
Disease control OngoingThis trial tests whether inhaling molgramostim—a lab-made version of a protein that helps lung cells clear out protein buildup—can improve lung function in adults with autoimmune pulmonary alveolar proteinosis (aPAP). In this condition, the immune system blocks a key signal, caus…
Phase 3 • Sponsor: Savara Inc. • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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AI takes on pap smears: could it match human experts?
Diagnosis By invitation onlyThis study compares a new AI-assisted digital system to the standard manual method for reading Pap tests. About 4,600 cervical cell samples will be reviewed both ways to see if the AI system is just as good at detecting abnormal cells. The goal is to determine if the AI can help …
Sponsor: Techcyte, Inc. • Aim: Diagnosis
Last updated Jun 26, 2026 13:35 UTC
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Rare disease study pulled before starting: scientists sought clues in cell stress
Knowledge-focused CancelledThis study was planned to learn how certain rare genetic mutations disrupt protein production and cause severe diseases affecting the lungs, liver, brain, and digestion. Researchers would have used cells from patients to measure protein levels and stress responses. However, the s…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC