Pseudohypoparathyroidism
MONDO:0019992Pseudohypoparathyroidism (PHP) is a heterogeneous group of endocrine disorders characterized by normal renal function and resistance to the action of parathyroid hormone (PTH), manifesting with hypocalcemia, hyperphosphatemia and elevated PTH levels and that includes the subtypes PHP type 1a (PHP-1a), PHP type 1b (PHP-1b), PHP type 1c (PHP-1c), PHP type 2 (PHP-2) and pseudopseudohypoparathyroidism (PPHP).
12 clinical trials for this condition and its sub-types.
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Broader categories
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Single-Patient trial aims to tackle obesity in rare bone disorder
Disease control ENROLLING_BY_INVITATIONThis phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…
Phase: PHASE2 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Old asthma drug shows promise for rare genetic disorder
Disease control OngoingThis phase 2 trial tests whether theophylline, a drug used for asthma, can help people with pseudohypoparathyroidism lose weight and improve blood sugar control. The study includes 29 obese participants aged 13 and older. Researchers will measure changes in body mass index and gl…
Phase: PHASE2 • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Could a common asthma drug help treat a rare genetic disorder?
Disease control ENROLLING_BY_INVITATIONThis study tests whether theophylline, a drug used for asthma, can help children and young adults with pseudohypoparathyroidism—a rare genetic condition causing early obesity, hormone problems, and short stature. Researchers will check for weight loss, better blood sugar control,…
Phase: PHASE2 • Sponsor: Jaclyn Tamaroff • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Old asthma drug could help kids with rare bone and hormone disorder
Disease control OngoingThis phase 2 trial tests theophylline, a drug used for asthma, in 34 children aged 2 to 12 with pseudohypoparathyroidism, a genetic condition causing obesity, short stature, and hormone resistance. The study aims to see if theophylline can help with weight loss, slow bone growth …
Phase: PHASE2 • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Can a placental patch make neck surgery scars heal better?
Symptom relief ENROLLING_BY_INVITATIONThis study tests whether placing a placental-based allograft called Amnioeffect on the surgical wound improves scar appearance, pain, and swallowing after thyroid or parathyroid surgery. About 334 adults will be enrolled, with half receiving the graft and half getting standard ca…
Phase: NA • Sponsor: Sarasota Memorial Health Care System • Aim: Symptom relief
Last updated Aug 05, 2026 00:00 UTC
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New needle method may better protect voice nerves during neck surgery
Knowledge-focused ENROLLING_BY_INVITATIONThis study compares two methods of monitoring the nerve that controls the vocal cords during thyroid and parathyroid surgery. The standard method uses a breathing tube with electrodes, while the new method uses tiny needles placed directly into the voice box cartilage. Researcher…
Phase: NA • Sponsor: Aristotle University Of Thessaloniki • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Long-Term study sheds light on rare bone and hormone disorder
Knowledge-focused OngoingThis study follows 600 people with Albright hereditary osteodystrophy, a rare genetic condition affecting bones and hormones. Researchers are looking at how growth hormone treatment affects height and weight in those with a related hormone problem, and also studying thinking and …
Phase: NA • Sponsor: Connecticut Children's Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:01 UTC