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Progressive external ophthalmoplegia

MONDO:0005181

A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)

Also known as: chronic progressive external ophthalmoplegia [ambiguous], progressive external ophthalmoplegia, chronic progressive external ophthalmoplegia

23 clinical trials for this condition and its sub-types.

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Sub-types

Kearns-Sayre syndrome (5) Autosomal dominant progressive external ophthalmoplegia (1) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2 (1) Autosomal recessive progressive external ophthalmoplegia (0) Mitochondrial DNA deletion syndrome with progressive myopathy (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 1 (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 3 (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 4 (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 5 (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 1 (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2 (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3 (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 (0) Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 5 (0) Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6 (0)

Broader categories

Disease (680) Metabolic disease (233) Nervous system disorder (231) Musculoskeletal system disorder (207) Hereditary disease (176) Central nervous system disorder (107) Inborn mitochondrial metabolism disorder (58) Muscle tissue disorder (56) Inborn errors of metabolism (45) Mitochondrial disease (40)
Trials to join now! 12 Not yet recruiting 2 Not yet finished but already full! 4 Completed 4 Terminated 1
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