Primary biliary cholangitis
MONDO:0005388Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.
Also known as: Hanot syndrome, PBC, chronic non-suppurative destructive cholangitis, chronic nonsuppurative destructive cholangitis, primary Bilary cirrhosis (PBC), primary biliary cirrhosis, biliary cirrhosis, primary, familial primary biliary cirrhosis
73 clinical trials for this condition and its sub-types.
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Broader categories
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New combo therapy aimed at Hard-to-Treat liver disease
Disease control TerminatedThis study tested whether combining two drugs, obeticholic acid and bezafibrate, could improve liver health in people with primary biliary cholangitis (PBC) who did not respond well to or could not take the standard medicine. The trial enrolled 75 adults and measured changes in a…
Phase: PHASE2 • Sponsor: Intercept Pharmaceuticals • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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PBC drug combo safety check ends early
Disease control TerminatedThis study looked at the long-term safety of a fixed-dose combination of two drugs (obeticholic acid and bezafibrate) for people with primary biliary cholangitis (PBC), a chronic liver disease. It enrolled 62 adults who had already been taking the combination in earlier studies. …
Phase: PHASE3 • Sponsor: Intercept Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Blood test may tame the tightrope walk of transplant drugs
Diagnosis TerminatedThis study tests whether a blood test called TruGraf can help doctors fine-tune immunosuppression medications in liver transplant recipients with autoimmune liver diseases like autoimmune hepatitis, primary sclerosing cholangitis, or primary biliary cirrhosis. The test measures g…
Sponsor: Washington University School of Medicine • Aim: Diagnosis
Last updated Aug 09, 2026 00:00 UTC
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Ear device aims to cut opioid use after liver transplant
Symptom relief TerminatedThis study tested a small device worn on the ear that uses mild electrical pulses to help control pain after a liver transplant. The goal was to see if it could reduce the need for strong painkillers like opioids. The study was stopped early and included 27 adults waiting for a l…
Phase: NA • Sponsor: Duke University • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC