Potassium-aggravated myotonia

MONDO:0018959

Potassium-aggravated myotonia (PAM) is a muscular channelopathy presenting with a pure myotonia dramatically aggravated by potassium ingestion, with variable cold sensitivity and no episodic weakness. This group includes three forms: myotonia fluctuans, myotonia permanens, and acetazolamide-responsive myotonia.

Also known as: K+-aggravated myotonia, K-aggravated myotonia, PAM, Potassium aggravated myotonia, myotonia congenita, atypical, acetazolamide-responsive, Laryngospasm, Severe Neonatal Episodic, MYOTONIA, POTASSIUM-AGGRAVATED, Myotonia Congenita, Acetazolamide-Responsive

34 clinical trials for this condition and its sub-types.

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Sub-types

Acetazolamide-responsive myotonia (0) Myotonia fluctuans (0) Myotonia permanens (0)

Broader categories

Disease (618) Nervous system disorder (217) Musculoskeletal system disorder (196) Hereditary disease (172) Neuromuscular disease (98) Muscle tissue disorder (53) Syndromic disease (24) Human disease (14) Myotonic syndrome (10) Skeletal muscle disorder (8)

Trials to join now! 15 Not yet recruiting 7 Not yet finished but already full! 4 Completed 7 Terminated 1

Scientists gather leftover surgical tissue to unlock secrets of bone disease

Knowledge-focused Terminated

This study collected bone, cartilage, skin, and fat tissue from 50 patients undergoing surgery at Children's National Medical Center. The goal was to grow cells from these tissues in the lab and analyze them to better understand bone and connective tissue diseases. The study was …

Sponsor: National Institute of Dental and Craniofacial Research (NIDCR) • Aim: Knowledge-focused

Last updated Jun 27, 2026 07:52 UTC

Potassium-aggravated myotonia

Sub-types

Broader categories

Scientists gather leftover surgical tissue to unlock secrets of bone disease