Post-treatment Lyme disease syndrome
MONDO:0700280A disorder caused by the infection in Lyme disease and manifesting after the original infection.
Also known as: PLDS, disorder due to consequences of Lyme disease, post-Lyme disease, post-Lyme disease syndrome, post-treatment Lyme disease syndrome
16 clinical trials for this condition and its sub-types.
Follow this condition to get notified about new trialsBroader categories
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Can a common antibiotic ease lingering lyme fatigue?
Symptom relief CompletedThis study tested whether taking tetracycline for 3 months is tolerable for people with Post-Treatment Lyme Disease (PTLD) — those who still have symptoms like fatigue after standard antibiotic treatment. 60 adults received either tetracycline or a placebo, then switched treatmen…
Phase 2 • Sponsor: Johns Hopkins University • Aim: Symptom relief
Last updated Jun 27, 2026 13:08 UTC
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Zapping a nerve in the ear might ease lingering lyme disease symptoms
Symptom relief CompletedThis pilot study tested a device called RAVANS that delivers mild electrical pulses to a nerve in the ear, aiming to reduce symptoms of post-treatment Lyme disease syndrome (PTLDS). Fifteen adults with PTLDS received either real or sham stimulation. The main goal was to see if th…
Sponsor: Spaulding Rehabilitation Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Scientists use clean ticks to sniff out hidden lyme infection
Knowledge-focused CompletedThis study tested whether clean, lab-bred ticks could find leftover Lyme bacteria in people who had been treated with antibiotics. 45 participants, including those with recent or past Lyme disease and healthy volunteers, had ticks placed on their skin for a few days. The goal was…
Early phase 1 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC