Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG
MONDO:0018977Polyneuropathy associated with IgM monoclonal gammapathy (MG) with anti-MAG (myelin-associated-glycoprotein) activity is a demyelinating polyneuropathy characterized clinically by sensory ataxia, tremor, paresthesia, and impaired gait.
Also known as: anti-MAG neuropathy, neuropathy associated with monoclonal IgM antibodies to myelin-associated glycoprotein
11 clinical trials for this condition and its sub-types.
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New drug combo aims to ease nerve pain in rare blood disorder
Disease control OngoingThis phase 2 trial tests whether the drug zanubrutinib, combined with standard rituximab, can improve nerve damage and disability in people with a rare blood condition called IgM MGUS. The study includes 35 adults across two Dutch hospitals. Participants take zanubrutinib daily f…
Phase: PHASE2 • Sponsor: UMC Utrecht • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Laser light shows promise for rare nerve pain
Symptom relief ENROLLING_BY_INVITATIONThis study tests whether photobiomodulation (low-level laser therapy) can reduce pain and disability in people with anti-MAG neuropathy, a rare nerve condition. Ten participants will receive 16 laser sessions over six weeks. Researchers will measure changes in disability, pain, a…
Sponsor: Centre Hospitalier de Cornouaille • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC