Polyhydramnios, megalencephaly, and symptomatic epilepsy
MONDO:0012611A syndrome characterized by polyhydramnios, distinctive craniofacial features, infantile-onset epilepsy, hypotonia, macrocephaly, and global developmental delay that has material basis in homozygous mutation in the STRADA gene on chromosome 17q23.3.
Also known as: PMSE syndrome, polyhydramnios, megalencephaly, and symptomatic epilepsy, PMSE, polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome, polyhydramnios-megalencephaly-symptomatic epilepsy syndrome, pretzel syndrome
7 clinical trials for this condition and its sub-types, 0 tagged with Polyhydramnios, megalencephaly, and symptomatic epilepsy itself.
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New inhaler aims to halt seizures in seconds
Disease control Recruiting nowThis Phase 3 trial tests a single inhaled dose of alprazolam (a fast-acting sedative) to stop prolonged seizures in people aged 12 and older. The goal is to see if it can end a seizure within 90 seconds and prevent it from coming back for at least 2 hours. About 350 participants …
Phase 3 • Sponsor: UCB Biopharma SRL • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Can a new Add-On seizure drug stay safe for kids over time?
Disease control Recruiting nowThis trial is testing the long-term safety of brivaracetam, an anti-seizure medication, when used alongside other epilepsy treatments in children. Researchers are monitoring for side effects, including serious ones, over an extended period. The study includes children who previou…
Phase 3 • Sponsor: UCB Biopharma SRL • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Rehearsal and sleep: unlocking memory secrets in epilepsy
Knowledge-focused Recruiting nowThis study investigates how rehearsal (repeating information) and sleep help solidify memories in people with epilepsy. Participants learn object-location pairs, with some pairs rehearsed and others not, and their memory is tested after a short delay and again after 12 hours—eith…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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Super MRI scans aim to unlock secrets of brain resilience
Knowledge-focused Recruiting nowThis study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…
Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC