Pineoblastoma
MONDO:0016722Pineoblastoma is a rare, malignant type of supratentorial primitive neuroectodermal tumor (sPNET), found mainly in children (less than 10% of cases are reported in adults), and located in the pineal region of the brain but that can metastasize along the neuroaxis. As it is the most aggressive of the pineal parenchymal tumors, it is usually associated with a poor prognosis.
Also known as: PNET of pineal gland, PNET of the pineal gland, pineal PNET, pineal gland PNET, pineal gland primitive neuroectodermal neoplasm, pineal gland primitive neuroectodermal tumor, pineal gland primitive neuroectodermal tumour, pineal primitive neuroectodermal neoplasm
2850 clinical trials for this condition and its sub-types, 15 tagged with Pineoblastoma itself.
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Browse by category →Sub-types of Pineoblastoma
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Adult pineoblastoma 0 trials
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Intensive chemo combo shows promise for kids with aggressive brain cancer
Disease control OngoingThis study tests whether giving three rounds of very strong chemotherapy with stem cell rescue works better than one round for children under 10 with high-risk brain tumors. The goal is to improve survival without adding too many side effects. About 250 children will take part.
Phase 4 • Sponsor: Parth Patel • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New hope for young brain tumor patients: chemotherapy first, then targeted radiation
Disease control OngoingThis clinical trial tests a risk-adapted approach for young children with newly diagnosed brain tumors. The treatment starts with chemotherapy to delay radiation, giving the brain more time to develop. Then, radiation is carefully targeted to the tumor area to reduce side effects…
Phase 2 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Engineered immune cells injected directly into brain show promise for kids with deadly tumors
Disease control OngoingThis early-phase study tests whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with HER2-positive brain tumors that have come back or not responded to standard treatments. The therapy a…
Phase 1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC