Peritoneal mesothelioma

This early-stage trial is testing a new drug called IDE892, alone or with another drug (IDE397), in people with advanced solid tumors that have a specific genetic deletion (MTAP). The study aims to find safe doses and see if the drugs shrink tumors. It includes 260 adults with ca…

This phase 2 trial is testing whether adding the immunotherapy drug atezolizumab to standard chemotherapy (carboplatin, pemetrexed, and bevacizumab) works better than chemotherapy alone for peritoneal mesothelioma, a rare cancer of the abdominal lining. About 66 people will take …

This phase 2 trial tests whether giving chemotherapy directly into the abdomen (intraperitoneal) or into a vein (intravenous) after surgery and heated chemotherapy works better for people with malignant peritoneal mesothelioma. Participants must have had successful removal of vis…

This study tests a new way to choose cancer treatments for people with peritoneal mesothelioma. After surgery, doctors will grow a model of the patient's tumor in the lab and test different drugs on it to find the best match. The goal is to see if this personalized approach helps…

This study tests whether a daily breathing exercise called cardiac coherence can lower anxiety in people awaiting surgery for peritoneal cancer. About 60 participants will either practice the technique or receive standard care. The goal is to see if this simple, drug-free method …

This study collects follow-up data from 125 people with peritoneal surface cancers, including colorectal-origin carcinomatosis, pseudomyxoma peritonei, and peritoneal mesothelioma, who are scheduled for cytoreductive surgery combined with HIPEC. The goal is to track their outcome…

This study looks at a treatment called HIPEC, where heated chemotherapy is washed inside the abdomen after surgery to remove tumors. Researchers want to see if lab-grown tumor models can predict how well the chemotherapy works. Sixty adults with cancers that have spread to the ab…

This study collects and stores tissue and blood samples from people with stomach, esophageal, pancreatic, liver, and other gastrointestinal cancers. The goal is to build a large database of samples and medical information to help researchers understand these cancers better. Parti…

This study is looking at tumor samples from 220 people with pleural or peritoneal mesothelioma, a rare cancer linked to asbestos. Researchers will analyze the genes and immune cells in these tumors to find patterns that could predict which treatments work best. The goal is to imp…