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Paraneoplastic syndrome
MONDO:0021073A classification for rare disorders of diverse organ systems (endocrine, neuromuscular, gastrointestinal, renal, dermatologic, rheumatologic, hematologic) that are affected by substances secreted by a distant neoplasm but not by the action of the neoplasm itself metastasizing to that organ or tissue. Less than 1 % of neoplasms are associated with these syndromes. An immune-mediated response to neoplasm-elaborated proteins may be the cause of these syndromes. Additionally, their manifestation may signal the presence of an occult neoplasm, potentially at an earlier stage of disease thereby leading to a better clinical outcome. Constitutional signs may include fever, night sweats, anorexia and cachexia. Clinical course is usually progressive. Prognosis is variable depending on the effective treatment of the underlying neoplasm.
Also known as: paraneoplastic syndrome
14 clinical trials for this condition and its sub-types.
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Broader categories
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Could a stem cell transplant stop the immune system from attacking the brain?
Disease control OngoingThis phase 2 trial tests whether high-dose chemotherapy followed by a stem cell transplant can stop the immune system from attacking the nervous system in people with autoimmune neurologic diseases like multiple sclerosis and stiff person syndrome. The treatment aims to weaken th…
Phase: PHASE2 • Sponsor: Fred Hutchinson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Can Full-Body scans spot cancer early in High-Risk families?
Diagnosis OngoingThis study is testing whether whole body MRI scans can help find cancers early in children and adults with Li-Fraumeni syndrome, a genetic condition that greatly raises cancer risk. About 150 participants will receive annual whole body MRI scans for four years to see if they keep…
Phase: NA • Sponsor: Dana-Farber Cancer Institute • Aim: Diagnosis
Last updated Jun 27, 2026 08:08 UTC
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New test could predict falls in muscle disease patients
Diagnosis ENROLLING_BY_INVITATIONThis study aims to create a simple test battery to determine fall risk in people with neuromuscular disorders, such as muscular dystrophy or ALS. Researchers will assess 108 participants using several physical tests like walking, standing, and rising from a chair. The goal is to …
Sponsor: LMU Klinikum • Aim: Diagnosis
Last updated Jun 26, 2026 16:30 UTC
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Desperate patient gets own stem cells for rare nerve disease
Symptom relief NO_LONGER_AVAILABLEThis study treated one 58-year-old man with polyneuropathy caused by POEMS syndrome using his own fat-derived stem cells. He received eight infusions over 28 weeks to try to relieve nerve symptoms. The study is no longer available and was not a formal clinical trial.
Sponsor: Hope Biosciences Research Foundation • Aim: Symptom relief
Last updated Jun 27, 2026 07:52 UTC
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Researchers track rare bone disease over years in observational study
Knowledge-focused OngoingThis study follows 23 people with tumor-induced osteomalacia (TIO), a rare condition where tumors cause weak bones. The goal is to see how well the drug burosumab works over time and to monitor any tumor changes. Participants continue their usual care, and no new treatments are g…
Sponsor: Ultragenyx Pharmaceutical Inc • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC