Oral cavity carcinoma in situ

This study tests three new ways to deliver the chemotherapy drug cisplatin directly to tumors in the mouth or lungs. The goal is to kill cancer cells while reducing side effects on the rest of the body. About 40 adults with early-stage oral or lung cancer will receive the treatme…

This phase 2 trial tests whether APG-157, a plant-based pastille taken three times daily, can shrink or eliminate precancerous growths in the mouth. Researchers will enroll 32 adults with moderate to severe oral dysplasia or carcinoma in situ. The goal is to see if the treatment …

This study follows 300 people with oral lichen planus (a chronic mouth condition) for at least 6 months to see how often it turns into oral cancer. Researchers will also look for patterns and risk factors that might predict this change. No new treatments are tested—the goal is si…

This study is for 1000 people with oral cancer or precancerous mouth lesions. Researchers will collect tissue samples and ask participants about their symptoms before, during, and after treatment. The goal is to find better ways to predict how the disease will behave and which tr…