Optic nerve disorder
MONDO:0002135A non-neoplastic or neoplastic disorder affecting the optic nerve (second cranial nerve).
Also known as: cranial nerve II disease, cranial nerve II disease or disorder, disease of cranial nerve II, disease or disorder of cranial nerve II, disorder of cranial nerve II, optic nerve disorder, second cranial nerve disorder
96 clinical trials for this condition and its sub-types, 23 tagged with Optic nerve disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Optic nerve disorder
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Optic atrophy 4 trials · 26 incl. sub-types
3 sub-types
- Primary optic atrophy 0 trials · 23 incl. sub-types Sub-types →
- Glaucomatous atrophy of optic disk 0 trials
- Partial optic atrophy 0 trials
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Optic neuritis 21 trials · 25 incl. sub-types
5 sub-types
- Optic papillitis 5 trials Sub-types →
- Autoimmune optic neuritis 0 trials
- Retrobulbar neuritis 0 trials Sub-types →
- Toxic optic neuropathy 0 trials
- Toxic or nutritional optic neuropathy 0 trials
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Low tension glaucoma 21 trials
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Anterior ischemic optic neuropathy 9 trials · 11 incl. sub-types
2 sub-types
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Optic nerve neoplasm 1 trial · 4 incl. sub-types
3 sub-types
- Optic nerve glioma 2 trials · 3 incl. sub-types Sub-types →
- Optic nerve sheath meningioma 1 trial
- Bilateral meningioma of optic nerve 0 trials
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Optic disk drusen 1 trial
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Isolated optic nerve aplasia 0 trials
Most studied deeper sub-types
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New drug could beat steroids for saving sight in thyroid eye disease
Disease control Not yet recruitingThis study compares two treatments given after emergency eye surgery for people with thyroid eye disease who have vision loss. One group gets teprotumumab, a newer drug that blocks a growth factor, and the other gets high-dose steroids. The goal is to see which one better improve…
Phase 2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Could vitamin B3 save sight in rare genetic blindness?
Disease control Not yet recruitingThis early study tests whether high-dose vitamin B3 (nicotinamide) can help preserve or improve vision in people with Leber's hereditary optic neuropathy (LHON), a rare genetic disease that causes sudden vision loss. Researchers will give 13 participants 2 grams of vitamin B3 dai…
Phase 1 • Sponsor: University Hospital, Angers • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New MRI techniques could sharpen diagnosis of optic nerve inflammation
Diagnosis Not yet recruitingThis study tests whether two advanced MRI techniques, called Double Inversion Recovery (DIR) and Diffusion Tensor Imaging (DTI), can improve the assessment of optic neuritis—inflammation of the optic nerve that can affect vision. Researchers will compare MRI measurements of the a…
Sponsor: Assiut University • Aim: Diagnosis
Last updated Aug 08, 2026 00:03 UTC
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Eye ultrasound could help doctors spot hidden inflammation in blood vessel disease
Diagnosis Not yet recruitingThis study looks at how quickly the optic nerve sheath shrinks after starting steroids in people with giant cell arteritis, a condition that can cause blindness. Researchers will use eye ultrasounds and blood tests over two months in 60 newly diagnosed patients. The goal is to fi…
Sponsor: Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal • Aim: Diagnosis
Last updated Jun 27, 2026 12:04 UTC