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O'Sullivan-McLeod syndrome

MONDO:0020559

O'Sullivan McLeod syndrome is a benign lower motor neuron disorder and a rare variant of monomelic amyotrophy (MA), characterized by an initial unilateral weakness in the intrinsic hand muscles that eventually spreads to the opposite limb (with an asymmetrical distribution) and that has a very slow progression of muscular atrophy over a 20 year period.

20 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Nervous system disorder (217) Neurodegenerative disease (155) Neuromuscular disease (98) Central nervous system disorder (97) Motor neuron disorder (59) Human disease (14) Acquired motor neuron disease (0) Disease by body system or component (0) Monomelic amyotrophy (0)
Trials to join now! 12 Not yet recruiting 1 Not yet finished but already full! 3 Completed 4
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  • Could a zapping cap boost memory? small study tests brain stimulation for cognitive decline

    Symptom relief Not yet recruiting

    This pilot study will test whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive low-level electrica…

    Phase: NA • Sponsor: Sunnybrook Health Sciences Centre • Aim: Symptom relief

    Last updated Jun 27, 2026 12:28 UTC

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