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NIK deficiency

MONDO:0018642

A immunodeficiency disorder caused by loss of function mutation in NIK (MAP3K14).

Also known as: MAP3K14 non-severe combined immunodeficiency, non-severe combined immunodeficiency caused by mutation in MAP3K14, primary immunodeficiency with multifaceted aberrant lymphoid immunity

15 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Hereditary disease (172) Immune system disorder (140) Immunodeficiency disease (48) Human disease (14) Combined immunodeficiency (3) Disease of genetic or genomic mechanism (2) Disease by body system or component (0) Disease by etiologic mechanism (0) Non-SCID combined immunodeficiency (0)
Trials to join now! 11 Completed 3 Terminated 1
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  • New stem cell method aims to protect kids with rare immune disease

    Disease control Terminated

    This study tested a way to improve stem cell transplants for children with combined immunodeficiency (CID), a condition where the immune system doesn't work properly. The approach removed certain naive cells from the donor stem cells to try to prevent graft-versus-host disease (a…

    Phase: PHASE2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control

    Last updated Jun 27, 2026 12:02 UTC

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