Neuronal ceroid lipofuscinosis 10
MONDO:0012414A rare condition that affects the nervous system. Signs and symptoms of the condition can develop any time from birth to adulthood and may include progressive dementia, seizures, lack of muscle coordination, and vision loss. CLN10-NCL is caused by changes (mutations) in the CTSD gene and is inherited in an autosomal recessive manner. Treatment options are limited to therapies that can help relieve some of the symptoms.
Also known as: CLN10, CLN10-NCL, CTSD neuronal ceroid lipofuscinosis, ceroid lipofuscinosis, neuronal, type 10, neuronal ceroid lipofuscinosis caused by mutation in CTSD, neuronal ceroid lipofuscinosis due to cathepsin D deficiency, neuronal ceroid lipofuscinosis type 10, CLN10 disease
2 clinical trials for this condition and its sub-types.
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Broader categories
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Scientists launch major study to unlock secrets of deadly batten disease
Knowledge-focused Recruiting nowThis study follows 300 people with CLN3 Batten disease, a rare genetic disorder that causes vision loss, seizures, and decline in thinking and movement. Researchers collect samples like blood and spinal fluid to find biological markers that could be used in future treatment trial…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Scientists track batten disease to unlock its secrets
Knowledge-focused Recruiting nowThis study follows 500 children and adults with Batten disease to learn how the condition naturally changes over time. Researchers will measure movement, thinking, behavior, and daily function using a special rating scale. The goal is to better understand the disease and improve …
Sponsor: University of Rochester • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:36 UTC