Nephrotic syndrome
MONDO:0005377A collection of symptoms that include severe edema, proteinuria, and hypoalbuminemia; it is indicative of renal dysfunction.
Also known as: nephrotic syndrome, nephrotic syndromes, syndrome, nephrotic, syndromes, nephrotic, nephrosis
71 clinical trials for this condition and its sub-types, 47 tagged with Nephrotic syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Nephrotic syndrome
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Idiopathic nephrotic syndrome 13 trials · 24 incl. sub-types
5 sub-types
- Idiopathic multidrug-resistant nephrotic syndrome 6 trials
- Idiopathic steroid-sensitive nephrotic syndrome 4 trials Sub-types →
- Sporadic idiopathic steroid-resistant nephrotic syndrome 0 trials · 2 incl. sub-types Sub-types →
- Familial idiopathic steroid-resistant nephrotic syndrome 0 trials Sub-types →
- Idiopathic steroid-resistant nephrotic syndrome with sensitivity to second-line immunosuppressive therapy 0 trials
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Familial nephrotic syndrome 0 trials · 22 incl. sub-types
18 sub-types
- Immunoglobulin-mediated membranoproliferative glomerulonephritis 12 trials
- Idiopathic multidrug-resistant nephrotic syndrome 6 trials
- Nephrotic syndrome 14 3 trials
- Nephrotic syndrome, type 4 1 trial
- LAMB2-related infantile-onset nephrotic syndrome 0 trials Sub-types →
- Congenital nephrotic syndrome, Finnish type 0 trials
- Familial idiopathic steroid-resistant nephrotic syndrome 0 trials Sub-types →
- Nephrotic syndrome 15 0 trials
- Nephrotic syndrome 16 0 trials
- Nephrotic syndrome, IIa 26 0 trials
- Nephrotic syndrome, type 17 0 trials
- Nephrotic syndrome, type 18 0 trials
- Nephrotic syndrome, type 19 0 trials
- Nephrotic syndrome, type 20 0 trials
- Nephrotic syndrome, type 21 0 trials
- Nephrotic syndrome, type 22 0 trials
- Nephrotic syndrome, type 23 0 trials
- Nephrotic syndrome, type 24 0 trials
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Steroid-resistant nephrotic syndrome 5 trials · 15 incl. sub-types
4 sub-types
- Nephrotic syndrome of childhood - steroid sensitive 5 trials
- Nephrotic syndrome 14 3 trials
- Sporadic idiopathic steroid-resistant nephrotic syndrome 0 trials · 2 incl. sub-types Sub-types →
- Familial idiopathic steroid-resistant nephrotic syndrome 0 trials Sub-types →
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Nephrotic syndrome ocular anomalies 0 trials
Most studied deeper sub-types
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CAR-T therapy aimed at tough kidney disease in kids — but trial never started
Disease control CancelledThis was a planned early-stage trial to test whether anti-CD19 CAR-T cells could safely help children with multi-drug resistant nephrotic syndrome, a serious kidney condition. The study was withdrawn before any patients were enrolled, so no data on safety or effectiveness were co…
Phase 1 • Sponsor: The Children's Hospital of Zhejiang University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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New hope for kids with tough kidney disease: obinutuzumab may replace steroids
Disease control OngoingThis study tests a new drug called obinutuzumab in 100 children aged 1-18 with refractory nephrotic syndrome, a kidney condition causing swelling and protein loss. The drug targets immune cells to reduce disease flares and dependence on steroids and other medications. Researchers…
Sponsor: Children's Hospital of Chongqing Medical University • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Could less steroid be just as good for kids with kidney disease?
Disease control OngoingThis study tests whether a lower dose of the steroid prednisone can treat relapses of nephrotic syndrome in children as effectively as the standard dose. Fifty children aged 1 to 18 with active relapses will be randomly assigned to either the reduced-dose or standard-dose regimen…
Phase 3 • Sponsor: The Hospital for Sick Children • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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New hope for kids with kidney disease: drug may cut relapses and steroids
Disease control OngoingThis study tests a drug called obinutuzumab against a standard treatment (MMF) in children and young adults with a kidney condition that causes frequent relapses. The goal is to see if obinutuzumab can keep the disease in remission longer and reduce the need for steroids. About 8…
Phase 3 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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Scientists hunt for genes behind kidney disease
Knowledge-focused OngoingThis study aims to find the genetic causes of kidney diseases like FSGS and nephrotic syndrome. Researchers will collect saliva and urine samples from up to 2,050 participants, including patients and their family members, as well as healthy volunteers. The goal is to understand w…
Sponsor: Beth Israel Deaconess Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Hidden calcium risk in Steroid-Treated kids
Knowledge-focused OngoingThis study looks at how often children with steroid-dependent nephrotic syndrome have high calcium levels in their urine (hypercalciuria). Researchers will check 50 children aged 2 to 16 who are on steroid treatment. The goal is simply to find out how common this condition is, no…
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Which kidney test is more accurate? new study aims to find out
Knowledge-focused OngoingThis observational study compares two common blood tests—creatinine and cystatin C—to see which one better estimates actual kidney function in people with nephrotic syndrome. Researchers will use stored blood samples from 50 participants in three ongoing clinical trials. The goal…
Sponsor: Mario Negri Institute for Pharmacological Research • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:33 UTC