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Myositis ossificans
MONDO:0003964A disorder characterized by non-neoplastic bone formation in soft tissues. It usually follows blunt trauma and bleeding in the deep soft tissues.
Also known as: FOP, myositis ossificans progressiva, progressive myositis ossificans, progressive ossifying myositis, fibrodysplasia ossificans progressiva
13 clinical trials for this condition and its sub-types, 11 tagged with Myositis ossificans itself.
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Sub-types of Myositis ossificans
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Traumatic myositis ossificans 0 trials
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Promising drug combo may stop painful flare-ups in rare bone disease
Disease control Recruiting nowThis study looks at whether anti-inflammatory drugs (like anakinra or canakinumab) can reduce painful flare-ups and prevent extra bone growth in people with a rare genetic condition called fibrodysplasia ossificans progressiva (FOP). Eleven people with severe FOP will be tracked …
Sponsor: University of California, San Francisco • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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New drug aims to stop extra bone formation in rare disease
Disease control Recruiting nowThis Phase 2 trial tests an experimental drug called INCB000928 (zilurgisertib) in people with fibrodysplasia ossificans progressiva (FOP), a rare genetic condition where soft tissues turn into bone. About 98 participants aged 2 and older will receive either the drug or a placebo…
Phase 2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New registry tracks Real-World safety of FOP drug palovarotene
Knowledge-focused Recruiting nowThis registry study follows about 100 people with FOP, a rare disease where soft tissue turns to bone. Some participants take palovarotene (an approved treatment), while others do not. Researchers will track side effects, flare-ups, and daily function over time to see how well th…
Sponsor: Ipsen • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Worldwide FOP database launches to unlock secrets of rare bone disease
Knowledge-focused Recruiting nowThis global registry collects information from people with Fibrodysplasia Ossificans Progressiva (FOP), a rare condition where soft tissues turn into bone. Up to 800 patients worldwide can report their symptoms, flare-ups, and mobility changes through a secure online portal. The …
Sponsor: The International FOP Association • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC