Muckle-Wells syndrome
MONDO:0008633An intermediate form of cryopyrin-associated periodic syndrome (CAPS) and is characterized by recurrent fever (with malaise and chills), recurrent urticaria-like skin rash, sensorineural deafness, general signs of inflammation (eye redness, headaches, arthralgia/myalgia) and potentially life-threatening secondary amyloidosis (AA type).
Also known as: Muckle-Wells syndrome, neutrophilic urticaria, Cryopyrin-associated periodic syndrome 2, MUCKLE-Wells syndrome, MWS, Muckle Wells syndrome, Uda syndrome, urticaria, deafness and amyloidosis
51 clinical trials for this condition and its sub-types.
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Pausing arthritis drug may boost pneumonia Shot's power
Disease control Not yet recruitingThis study tests whether temporarily stopping methotrexate for 2 weeks after receiving a pneumonia vaccine (PCV20) helps the vaccine work better in adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus. About 192 participants with stable, low disease activi…
Phase: PHASE4 • Sponsor: University of Sao Paulo General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New blood markers may speed up diagnosis of childhood arthritis and fevers
Diagnosis Not yet recruitingThis study looks at two substances in the blood, IL-18 and IL-18BP, to see if they can help doctors tell apart different causes of fever in children. Researchers will measure these levels in 9 children with conditions like juvenile arthritis, autoinflammatory diseases, or serious…
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna • Aim: Diagnosis
Last updated Jun 27, 2026 11:01 UTC
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Can a quick skin scan reveal hidden inflammation in arthritis?
Knowledge-focused Not yet recruitingThis study will measure harmful molecules called AGEs in 300 people with various rheumatic diseases (like rheumatoid arthritis and ankylosing spondylitis) and compare them to healthy volunteers. AGEs build up over time and can cause inflammation. Researchers will use a non-invasi…
Sponsor: Bursa City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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New blood tests aim to unlock mysteries of rare inflammatory diseases
Knowledge-focused Not yet recruitingThis study aims to better understand rare autoinflammatory diseases by developing blood tests that measure inflammation markers. Researchers will analyze blood samples from 60 adults and children with these conditions. The goal is to identify specific inflammation pathways, which…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:44 UTC