Motor neuron disorder
MONDO:0020128Neurological disease involving the motor neuron.
Also known as: anterior horn cell disease, disease of motor neuron, disease or disorder of motor neuron, disorder of motor neuron, motor neuron disease, motor neuron disease or disorder
510 clinical trials for this condition and its sub-types, 70 tagged with Motor neuron disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Motor neuron disorder
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Amyotrophic lateral sclerosis 331 trials · 345 incl. sub-types
4 sub-types
- Familial amyotrophic lateral sclerosis 2 trials · 29 incl. sub-types Sub-types →
- Progressive muscular atrophy 11 trials Sub-types →
- Sporadic amyotrophic lateral sclerosis 2 trials
- Amyotrophic lateral sclerosis with polyglucosan bodies 0 trials
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Hereditary motor neuron disease 1 trial · 169 incl. sub-types
9 sub-types
- Spinal muscular atrophy 107 trials · 117 incl. sub-types Sub-types →
- Familial amyotrophic lateral sclerosis 2 trials · 29 incl. sub-types Sub-types →
- Lateral sclerosis 24 trials Sub-types →
- Riboflavin transporter deficiency 1 trial · 6 incl. sub-types Sub-types →
- Distal hereditary motor neuropathy 0 trials · 4 incl. sub-types Sub-types →
- ALS2-related motor neuron disease 0 trials Sub-types →
- Motor neuron disease with dementia and ophthalmoplegia 0 trials
- Neurogenic scapuloperoneal syndrome, Kaeser type 0 trials
- Prenatal-onset spinal muscular atrophy with congenital bone fractures 0 trials Sub-types →
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Acquired motor neuron disease 0 trials · 39 incl. sub-types
3 sub-types
- Poliomyelitis 28 trials · 39 incl. sub-types Sub-types →
- Mills syndrome 0 trials
- Monomelic amyotrophy 0 trials Sub-types →
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Madras motor neuron disease 0 trials
Most studied deeper sub-types
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New ALS drug trial aims to tame inflammation
Disease control Not yet recruitingThis early-phase trial tests an oral drug, Kamlanoflast, in 40 people with ALS. Over 24 weeks, researchers will check safety, tolerability, and whether the drug reduces inflammation and slows decline in function. It is not yet recruiting.
Phase 1/2 • Sponsor: Inflammasome Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Blood test may slash ALS diagnosis time from months to days
Diagnosis Not yet recruitingThis study investigates whether measuring a protein called neurofilament light chain (NfL) in the blood can help doctors diagnose amyotrophic lateral sclerosis (ALS) more quickly and accurately. ALS is often hard to distinguish from other neurological diseases, leading to delays …
Sponsor: University Hospital, Montpellier • Aim: Diagnosis
Last updated Jul 22, 2026 00:00 UTC
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Can hope and trust boost engagement with rehab robots?
Knowledge-focused Not yet recruitingThis observational study looks at adults aged 18 to 85 with neurological conditions like stroke, Parkinson's disease, or spinal cord injury who use robotic or virtual reality tools in their rehabilitation. Researchers want to see if hope and the quality of the patient-provider re…
Sponsor: Catholic University, Italy • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Spinal stimulation trial aims to restore movement in paralyzed patient
Knowledge-focused Not yet recruitingThis pilot study will test whether temporarily stimulating nerves in the lower spine can improve movement and bladder function in one person with a spinal cord injury. The participant will have small electrodes placed near the spinal nerves and undergo 10 days of rehabilitation s…
Sponsor: Peter J. Grahn, Ph.D. • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Blood markers may unlock early ALS detection — a study puts them to the test
Knowledge-focused Not yet recruitingALS is a progressive nerve disease with no simple test for early diagnosis or tracking. This study is collecting blood samples and medical data from 200 people with ALS to look for patterns in proteins, genes, and immune markers. The goal is to build a biomarker panel that could …
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC
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New study aims to fix gaps in MND care across the UK
Knowledge-focused Not yet recruitingThis study aims to understand how care for people with Motor Neurone Disease (MND) is coordinated between specialist clinics and local community services. Researchers will talk to patients, carers, and healthcare professionals, and observe how care is transferred. The goal is to …
Sponsor: University of Sheffield • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC