Medullary thyroid gland carcinoma
MONDO:0015277A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy.
Also known as: C cell carcinoma, MTC, carcinoma of parafollicular cell, carcinoma, C-cell, malignant, medullary carcinoma, medullary carcinoma of the thyroid, medullary carcinoma of the thyroid gland, medullary carcinoma of thyroid
2831 clinical trials for this condition and its sub-types, 42 tagged with Medullary thyroid gland carcinoma itself.
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Browse by category →Sub-types of Medullary thyroid gland carcinoma
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Familial medullary thyroid carcinoma 23 trials
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Can a targeted pill be safely used for RET-Driven cancers in india?
Disease control Not yet recruitingResearchers are studying the safety of selpercatinib, an oral drug, in people in India with advanced cancers that have changes in the RET gene. The trial includes adults with RET fusion-positive non-small cell lung cancer and adults and children aged 12 and older with RET-mutant …
Phase 4 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Radioactive drug targets hard-to-treat neuroendocrine tumors in early trial
Disease control Not yet recruitingThis phase 1 trial tests a radioactive drug called 211At-MABG in 16 adults with advanced neuroendocrine cancers, including pheochromocytoma and paraganglioma. The drug delivers radiation directly to cancer cells that show up on a special scan. The main goal is to see if the treat…
Phase 1 • Sponsor: University of Pennsylvania • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Could a smaller surgery spare medullary thyroid cancer patients from lifelong pills?
Disease control Not yet recruitingThis study tests whether removing only the cancerous part of the thyroid and nearby lymph nodes on one side is safe and effective for sporadic medullary thyroid cancer. Currently, all patients get the entire thyroid removed, which requires lifelong hormone pills and carries highe…
Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:39 UTC
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New pill hopes to fight multiple cancers when other treatments fail
Disease control Not yet recruitingThis early-stage trial tests an experimental drug called ACC-1898, taken as a daily pill, in adults with advanced solid tumors (like liver, kidney, or stomach cancer) that have not responded to standard treatments. The main goals are to find a safe dose and see how the body handl…
Phase 1 • Sponsor: AccSalus Biosciences, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC