Mayer-Rokitansky-Kuster-Hauser syndrome
MONDO:0017771Spectrum of Mullerian duct anomalies characterized by congenital aplasia of the uterus and upper 2/3 of the vagina in otherwise phenotypically normal females. It can be classified as either MRKH syndrome type 1 (corresponding to isolated utero-vaginal aplasia) or MRKH syndrome type 2 (utero-vaginal aplasia associated with other malformations).
Also known as: MRKH, MRKH syndrome, Mayer-Rokitansky-Küster-Hauser Syndrome, Mullerian aplasia/dysgenesis, Rokitansky Kuster Hauser syndrome, Rokitansky syndrome, Mayer-Rokitansky-Küster-Hauser syndrome
10 clinical trials for this condition and its sub-types.
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Womb transplant trial offers hope for women born without a uterus
Disease control Recruiting nowThis study tests whether a donated uterus can help 10 women who were born without a uterus or had it removed to carry a pregnancy. Participants will receive a uterus from a living or deceased donor, then try in vitro fertilization (IVF) to become pregnant. The goal is a live birt…
Phase: NA • Sponsor: John Goss • Aim: Disease control
Last updated Jun 27, 2026 12:24 UTC
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Lab-Grown vaginas: first human trial launches
Disease control Recruiting nowThis Phase 1 trial tests a lab-grown vaginal implant made from a patient's own cells for women with vaginal aplasia (born without a vagina). Ten participants will receive the implant to see if it is safe and can improve quality of life. The implant is designed to mimic natural va…
Phase: PHASE1 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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New study aims to understand the emotional and sexual well-being of women with a rare uterine condition
Knowledge-focused Recruiting nowThis study looks at how Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, a rare condition where the uterus and vagina are underdeveloped, affects women's overall quality of life, sexual health, and mental well-being. Researchers will compare 102 women with MRKH to a control group …
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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25,000 ultrasound scans to train AI for better Women's health diagnosis
Knowledge-focused Recruiting nowThis study is creating a huge collection of ultrasound images from the uterus and ovaries. Researchers will gather scans from 25,000 women, both healthy and with gynecological conditions, during routine checkups. The goal is to build a database that doctors and artificial intelli…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Hysterectomy study seeks best stitch for better sex life
Knowledge-focused AVAILABLEThis study looks at different methods doctors use to close the vaginal cuff after laparoscopic hysterectomy (removal of the uterus). The goal is to see which technique helps preserve vaginal length and improve sexual function. Researchers will measure vaginal length with ultrasou…
Sponsor: Acibadem Kent Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC