Malignant mesothelioma

Researchers are testing whether adding vitamin B12 to standard chemotherapy helps people with pleural mesothelioma that cannot be removed by surgery. The trial gives participants pemetrexed and cisplatin, two chemotherapy drugs that block tumor cell growth in different ways, alon…

This trial is testing several different targeted drug combinations in people with mesothelioma that has returned after initial treatment. The goal is to see which therapies can control the disease and potentially improve survival. Participants are assigned to a treatment based on…

This study tested a new drug called PM8002, which targets two proteins that help cancer grow, combined with standard chemotherapy. It involved 31 adults with a rare cancer called malignant mesothelioma that could not be removed by surgery. The goal was to see if the combination s…

This study tested a drug called pembrolizumab in 65 people with malignant mesothelioma, a rare cancer of the lining around the lungs or abdomen. The drug works by helping the immune system attack cancer cells. The goal was to see if it could shrink tumors or slow the disease, but…

This early-stage trial tested an experimental drug called CTX-471, given alone or with the approved drug Keytruda, in 100 adults with advanced cancers like lung cancer, melanoma, and head and neck cancer. The goal was to see if the combination is safe and tolerable for patients w…

This early-phase trial tested a light-measuring system used during photodynamic therapy (PDT) for people with malignant mesothelioma, non-small cell lung cancer, or other pleural cancers. Nine participants received the drug porfimer sodium, which becomes active when exposed to li…

This study tested whether a combination of two immunotherapy drugs (nivolumab and ipilimumab) works better than standard chemotherapy for Chinese patients with advanced pleural mesothelioma, a rare cancer of the lung lining. 102 patients who could not have surgery were randomly a…

This phase 2 trial tested whether adding low-dose chemotherapy to radiation before surgery, followed by immunotherapy after surgery, could help people with malignant mesothelioma. Thirty participants were enrolled. The goal was to see if this approach boosts the immune system's a…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…