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Lymphatic malformation
MONDO:0019313Primary lymphedema is caused by anatomic or functional defects in the lymphatic system, resulting in chronic swelling of body parts and lymphatic-system malformation.
Also known as: hereditary lymphedema, lymphedema, hereditary
56 clinical trials for this condition and its sub-types, 17 tagged with Lymphatic malformation itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Lymphatic malformation
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Noonan syndrome 22 trials · 25 incl. sub-types
14 sub-types
- Noonan syndrome 3 2 trials
- Noonan syndrome 5 1 trial
- Noonan syndrome 1 0 trials
- Noonan syndrome 10 0 trials
- Noonan syndrome 11 0 trials
- Noonan syndrome 13 0 trials
- Noonan syndrome 14 0 trials
- Noonan syndrome 2 0 trials
- Noonan syndrome 4 0 trials
- Noonan syndrome 6 0 trials
- Noonan syndrome 7 0 trials
- Noonan syndrome 8 0 trials
- Noonan syndrome 9 0 trials
- Noonan syndrome 12 0 trials
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Lymphatic malformation 5 8 trials
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Lymphatic malformation 12 2 trials
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Dahlberg-Borer-Newcomer syndrome 0 trials
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Hennekam syndrome 0 trials
3 sub-types
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Norman-Roberts syndrome 0 trials
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Campomelia, Cumming type 0 trials
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Lymphatic malformation 1 0 trials
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Lymphatic malformation 10 0 trials
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Lymphatic malformation 11 0 trials
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Lymphatic malformation 13 0 trials
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Lymphatic malformation 14 0 trials
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Lymphatic malformation 2 0 trials
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Lymphatic malformation 3 0 trials
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Lymphatic malformation 4 0 trials
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Lymphatic malformation 6 0 trials
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Lymphatic malformation 7 0 trials
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Lymphatic malformation 8 0 trials
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Lymphatic malformation 9 0 trials
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Lymphedema-distichiasis syndrome 0 trials
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Yellow nail syndrome 0 trials
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Can a cancer drug shrink birthmarks? bleomycin injections put to the test
Disease control CompletedThis trial investigates whether injecting bleomycin directly into low-flow vascular malformations (abnormal clusters of blood or lymph vessels) in the head and neck can shrink them. Twenty participants will receive up to four sessions of the drug under local anesthesia. The main …
Phase 4 • Sponsor: University Of Anbar • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Shrinking birthmarks: bleomycin injections show promise for cystic hygromas in kids
Disease control CompletedThis study tested injecting bleomycin directly into cystic hygromas (fluid-filled birthmarks) in 30 children aged 1 month to 12 years. The fluid was drained and bleomycin injected, repeated every 4 weeks until the lump shrank. Most children saw significant size reduction, with so…
Sponsor: Delta University for Science and Technology • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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New cream shows promise for rare skin condition
Disease control CompletedThis study tested a cream containing sirolimus on rare skin growths called microcystic lymphatic malformations, which can ooze, bleed, and cause pain. 55 children and adults applied the cream to one area and a placebo cream to another for 12 weeks. The goal was to see if the siro…
Phase 2 • Sponsor: University Hospital, Tours • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Could a transplant drug tame tough vascular birthmarks?
Disease control CompletedThis phase 2 trial tested the drug sirolimus (rapamycin) in 61 children and young adults with complicated vascular anomalies—abnormal blood vessel growths that can cause pain, bleeding, or organ problems. The goal was to see if sirolimus could safely shrink these anomalies and im…
Phase 2 • Sponsor: Denise Martin Adams • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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New registry sheds light on rare overgrowth diseases
Knowledge-focused CompletedThis completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC