Locked-in syndrome
MONDO:0016567Locked-in syndrome (LIS) is a neurological condition characterized by the presence of sustained eye opening, quadriplegia or quadriparesis, anarthria, preserved cognitive functioning and a primary code of communication that uses vertical eye movements or blinking.
Also known as: Cerebromedullospinal disconnection, Locked In Syndrome, locked-in state
11 clinical trials for this condition and its sub-types.
Follow this condition to get notified about new trialsBroader categories
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Mind-Controlled computers: new device aims to help paralyzed veterans regain independence
Disease control Not yet recruitingThis study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …
Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Brain implant aims to give voice to those trapped in silence
Disease control Not yet recruitingThis study tests a fully wireless brain-computer interface (BCI) that aims to decode attempted speech in real time for people with locked-in syndrome (LIS), often caused by ALS or stroke. The implant records brain signals from areas controlling the mouth and throat, then translat…
Sponsor: University Hospital, Grenoble • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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Brain zaps aim to unlock movement in Locked-In patients
Symptom relief Not yet recruitingThis study tests whether combining two types of brain stimulation—tDCS and rTMS—can improve motor function in people with locked-in syndrome, a condition where the body is paralyzed but the mind is awake. Researchers will enroll 72 participants and randomly assign them to receive…
Sponsor: Zhujiang Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC