Locked-in syndrome
MONDO:0016567Locked-in syndrome (LIS) is a neurological condition characterized by the presence of sustained eye opening, quadriplegia or quadriparesis, anarthria, preserved cognitive functioning and a primary code of communication that uses vertical eye movements or blinking.
Also known as: Cerebromedullospinal disconnection, Locked In Syndrome, locked-in state
9 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Mind-Controlled computers: new device aims to help paralyzed veterans regain independence
Disease control Not yet recruitingThis study will test a mobile brain-computer interface (iBCI) that lets people with severe paralysis control computers and mobile devices using only their thoughts. Two veterans with conditions like spinal cord injury or ALS will use the device at home. The goal is to see if the …
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Brain zaps aim to unlock movement in Locked-In patients
Symptom relief Not yet recruitingThis study tests whether combining two types of brain stimulation—tDCS and rTMS—can improve motor function in people with locked-in syndrome, a condition where the body is paralyzed but the mind is awake. Researchers will enroll 72 participants and randomly assign them to receive…
Phase: NA • Sponsor: Zhujiang Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC