Brain zaps aim to unlock movement in Locked-In patients
NCT ID NCT07257601
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining two types of brain stimulation—tDCS and rTMS—can improve motor function in people with locked-in syndrome, a condition where the body is paralyzed but the mind is awake. Researchers will enroll 72 participants and randomly assign them to receive real or fake (sham) stimulation for 4 weeks. The goal is to see if the treatment helps with movement, as measured by standard motor and facial nerve tests, with follow-ups up to 6 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could point toward a non-invasive way to help people with locked-in syndrome regain some movement and independence.
What could go wrong
This is an early-stage trial with only 72 people, so results may not apply to everyone. The treatments are non-invasive but may not produce meaningful improvement, and the sham groups help test if any benefit is real.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.