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Leukocyte adhesion deficiency 1

MONDO:0007293

Leukocyte adhesion deficiency type I (LAD-I) is a form of LAD characterized by life-threatening, recurrent bacterial infections.

Also known as: leukocyte adhesion deficiency, ITGB2 leukocyte adhesion deficiency, LAD-I, LAD1, LFA-I deficiency, LFA1 immunodeficiency, lad-I, lad-type I

7 clinical trials for this condition and its sub-types.

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Broader categories

Disease (680) Hereditary disease (176) Hematologic disorder (170) Immune system disorder (148) Human disease (14) Leukocyte disorder (6) Autosomal recessive disease (4) Leukocyte adhesion deficiency (3) Disease of genetic or genomic mechanism (2) Autosomal genetic disease (0)

Trials to join now! 6 Not yet finished but already full! 1

Gene therapy for rare immune disease shows promise in Long-Term study

Disease control Ongoing

This study follows 9 people with a rare immune disorder called LAD-I who received a one-time gene therapy that adds a working copy of the ITGB2 gene to their own blood stem cells. Researchers want to see if the treatment safely controls the disease over many years and helps patie…

Sponsor: Rocket Pharmaceuticals Inc. • Aim: Disease control

Last updated Jun 27, 2026 08:05 UTC