Lennox-Gastaut syndrome
MONDO:0016532Lennox-Gastaut syndrome (LGS) belongs to the group of severe childhood epileptic encephalopathies.
Also known as: LGS, encephalopathy of childhood, epileptic encephalopathy Lennox-Gastaut type, macrocephaly and epileptic encephalopathy
40 clinical trials for this condition and its sub-types, 26 tagged with Lennox-Gastaut syndrome itself.
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Sub-types of Lennox-Gastaut syndrome
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Study tests safer switch from street CBD to approved drug for kids with severe epilepsy
Disease control Not yet recruitingThis study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…
Phase 4 • Sponsor: Elizabeth Donner • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Can a slow start with CBD oil tame Hard-to-Control seizures?
Disease control Not yet recruitingThis trial tests whether a gradual dosing schedule of cannabidiol oral solution (CBD-OS) can help reduce seizures in adults with Lennox-Gastaut syndrome, a severe form of epilepsy. Participants will take CBD oil alongside their usual seizure medications. The study measures how ma…
Phase 4 • Sponsor: Jazz Pharmaceuticals • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Smart brain pacemaker aims to stop seizures while you sleep
Disease control Not yet recruitingThis early study will test a new way to use deep brain stimulation (DBS) in 4 adults with Lennox-Gastaut syndrome, a severe form of epilepsy. The device will automatically adjust stimulation based on whether the person is awake or asleep. Researchers want to see if this personali…
Sponsor: University of Minnesota • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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Wearable EEG gadget aims to perfect seizure drug dosing at home
Knowledge-focused Not yet recruitingThis study tests whether a wearable device that records brain waves, heart rate, and movement at home can help doctors better adjust the dose of the seizure drug fenfluramine for people with Dravet syndrome or Lennox-Gastaut syndrome. Twenty patients will wear the device for 3-7 …
Sponsor: Byteflies • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC