Large cell neuroendocrine carcinoma
MONDO:0005057A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.
Also known as: LCNEC, large cell NEC, large cell neuroendocrine carcinoma, large-cell neuroendocrine carcinoma
2801 clinical trials for this condition and its sub-types, 12 tagged with Large cell neuroendocrine carcinoma itself.
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Browse by category →Sub-types of Large cell neuroendocrine carcinoma
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1 sub-type
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New hope for rare tumors: tarlatamab trial opens
Disease control OngoingThis study tests the drug tarlatamab in people with advanced tumors that have a protein called DLL3. The goal is to see if the drug can shrink or control these tumors. About 29 adults with stage IV cancer will receive tarlatamab, and researchers will track how well it works and a…
Phase 2 • Sponsor: Jonsson Comprehensive Cancer Center • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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Triple-Drug cocktail shows promise against rare neuroendocrine tumors
Disease control OngoingThis phase 2 trial is testing a combination of three drugs—cabozantinib, nivolumab, and ipilimumab—in 17 people with advanced neuroendocrine cancer that has spread. The goal is to see if the combination can shrink tumors or stop them from growing. Cabozantinib blocks enzymes that…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 02, 2026 00:00 UTC
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New drug combo tested for tough cancers
Disease control OngoingThis early-phase trial tests an investigational drug called ABBV-706, alone or combined with other drugs, in about 288 adults with advanced solid tumors like small cell lung cancer, high-grade brain tumors, and neuroendocrine cancers. The main goals are to check safety, find the …
Phase 1 • Sponsor: AbbVie • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC