Indolent systemic mastocytosis
MONDO:0020331Indolent systemic mastocytosis (ISM) is a benign form of systemic mastocytosis (SM) characterized by an abnormal proliferation of mast cells either only in bone marrow or in numerous tissues.
Also known as: ISM, indolent systemic mastocytosis (morphologic abnormality), ism
1861 clinical trials for this condition and its sub-types, 8 tagged with Indolent systemic mastocytosis itself.
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Sub-types of Indolent systemic mastocytosis
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Smouldering systemic mastocytosis 3 trials
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Isolated bone marrow mastocytosis 2 trials
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New pill aims to tame rare mast cell disease
Disease control Recruiting nowThis study tests an experimental drug called elenestinib (BLU-263) in people with indolent systemic mastocytosis, a rare condition where too many mast cells cause symptoms like flushing, itching, and stomach issues. About 534 participants will receive either the drug or a placebo…
Phase 2/3 • Sponsor: Blueprint Medicines Corporation • Aim: Disease control
Last updated Aug 06, 2026 00:00 UTC
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New hope for mastocytosis patients: expanded access to bezuclastinib
Disease control Expanded accessThis program provides the investigational drug bezuclastinib to adults with systemic mastocytosis who have failed or cannot tolerate standard treatments. Participants must be at least 18 years old and able to swallow tablets. The goal is to offer a potential treatment option when…
Sponsor: Cogent Biosciences, Inc. • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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New drug avapritinib under Real-World watch for mastocytosis relief
Disease control Recruiting nowThis study follows 80 people in Germany with indolent systemic mastocytosis whose symptoms are not well controlled by current treatments. Researchers will track how avapritinib affects quality of life and symptom control over up to 24 months in everyday medical practice. The goal…
Sponsor: Blueprint Medicines Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:10 UTC
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Blood test revolution: pinpointing the cause of swelling attacks
Diagnosis Recruiting nowThis study evaluates whether new blood tests can more accurately diagnose the cause of recurrent angioedema—a condition causing severe swelling—compared to current tests. Researchers will compare novel diagnostic assays with traditional ones in 600 people aged 12 and older who ha…
Sponsor: Foundation For Rare Disease Research • Aim: Diagnosis
Last updated Aug 26, 2026 00:00 UTC
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New study tracks daily life with rare mast cell disorder
Knowledge-focused Recruiting nowThis study watches how indolent systemic mastocytosis (ISM) affects people in everyday life. Researchers will collect information on symptoms, treatments, and quality of life from 150 adults. The goal is to better understand the disease and how it is managed, including the use of…
Sponsor: Blueprint Medicines Corporation • Aim: Knowledge-focused
Last updated Sep 06, 2026 00:00 UTC