Hyperthyroidism
MONDO:0004425Overactivity of the thyroid gland resulting in overproduction of thyroid hormone and increased metabolic rate. Causes include diffuse hyperplasia of the thyroid gland (Graves' disease), single nodule in the thyroid gland, and thyroiditis. The symptoms are related to the increased metabolic rate and include weight loss, fatigue, heat intolerance, excessive sweating, diarrhea, tachycardia, insomnia, muscle weakness, and tremor.
Also known as: overactive thyroid
70 clinical trials for this condition and its sub-types, 27 tagged with Hyperthyroidism itself.
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Sub-types of Hyperthyroidism
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Primary hyperthyroidism 1 trial · 59 incl. sub-types
3 sub-types
- Graves disease 53 trials Sub-types →
- Toxic multinodular goitre 7 trials
- Toxic thyroid adenoma 2 trials
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Toxic diffuse goiter 0 trials · 53 incl. sub-types
1 sub-type
- Graves disease 53 trials Sub-types →
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Thyrotoxicosis 2 trials
1 sub-type
- Neonatal thyrotoxicosis 0 trials
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Generalized resistance to thyroid hormone 1 trial · 2 incl. sub-types
6 sub-types
- Thyroid hormone resistance, generalized, autosomal dominant 2 trials
- Athyreosis 0 trials
- Thyroid ectopia 0 trials
- Thyroid hemiagenesis 0 trials
- Thyroid hormone resistance, generalized, autosomal recessive 0 trials
- Thyroid hypoplasia 0 trials
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Secondary hyperthyroidism 0 trials · 2 incl. sub-types
2 sub-types
- TSH producing pituitary tumor 0 trials · 2 incl. sub-types Sub-types →
- Hypothalamic hyperthyroidism 0 trials
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Familial gestational hyperthyroidism 0 trials
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Thyroid crisis 0 trials
Most studied deeper sub-types
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New injection every 8 weeks shows promise for thyroid eye disease
Disease control OngoingThis study tests a drug called TOUR006 in 79 people with active thyroid eye disease, a condition that causes eye bulging and inflammation. Participants receive either a low dose, high dose, or placebo injection every 8 weeks. The main goal is to see if the drug can reduce eye bul…
Phase 2 • Sponsor: Tourmaline Bio, Inc., a Novartis Company • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New registry to see if blocking thyroid blood flow improves symptoms
Disease control By invitation onlyThis registry study follows 100 adults who have had a procedure called thyroid embolization to treat hyperthyroidism, goiter, or thyroid nodules. The procedure uses a catheter to block blood flow to the thyroid, aiming to shrink it and reduce symptoms. Researchers will track chan…
Sponsor: Sarasota Memorial Health Care System • Aim: Disease control
Last updated Jun 26, 2026 14:53 UTC
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Tear test could spot eye disease risk in thyroid patients
Knowledge-focused OngoingThis research study aims to create a simple, non-invasive test using tears and blood to predict which patients with hyperthyroidism are at risk of developing Graves' Orbitopathy (eye disease). Researchers will analyze samples from 90 participants, including healthy controls and t…
Sponsor: University Hospital, Ghent • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Holistic education study for stress withdrawn before starting
Knowledge-focused CancelledThis study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …
Sponsor: Goddess Zena I. Jones • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Thyroid Surgery's heart impact study pulled before start
Knowledge-focused CancelledThis study aimed to see if thyroid surgery changes the thickness of the carotid artery, which is a sign of heart disease risk. It planned to measure artery thickness before and after surgery in adults with various thyroid conditions. However, the study was withdrawn before enroll…
Sponsor: Istituto Auxologico Italiano • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC