Hyperinsulinemic hypoglycemia
MONDO:0005803An inherited autosomal recessive syndrome characterized by the disorganized formation of new islets in the pancreas and congenital hyperinsulinism. It is due to focal hyperplasia of pancreatic islet cells budding off from the ductal structures and forming new islets of langerhans. Mutations in the islet cells involve the potassium channel gene kcnj11 or the atp-binding cassette transporter gene abcc8, both on chromosome 11.
Also known as: hyperinsulinemia hypoglycemia, hyperinsulinemic hypoglycemia (disease), nesidioblastosis
14 clinical trials for this condition and its sub-types.
Follow this condition to get notified about new trialsSub-types
Broader categories
-
New weekly shot shows promise for rare low blood sugar disorder
Disease control OngoingThis study tests a new medicine called HM15136 for people aged 2 and older with congenital hyperinsulinism (CHI) who still have low blood sugar despite standard treatments. The medicine is given as a weekly shot for 8 weeks. The goal is to see if it is safe and helps control bloo…
Phase 2 • Sponsor: Hanmi Pharmaceutical Company Limited • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
-
Promising new treatment for rare sugar disorder moves to final testing phase
Disease control OngoingThis study tests an investigational drug called RZ358 for people with congenital hyperinsulinism, a rare condition causing dangerously low blood sugar. The trial involves 56 participants aged 3 months to 45 years who still have low blood sugar despite standard treatments. Over 24…
Phase 3 • Sponsor: Rezolute • Aim: Disease control
Last updated Jun 27, 2026 08:09 UTC
-
Newborn screening study aims to catch rare diseases at birth
Diagnosis OngoingThis study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…
Sponsor: RTI International • Aim: Diagnosis
Last updated Jul 03, 2026 00:00 UTC