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Hereditary spastic paraplegia

MONDO:0019064

Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs.

Also known as: spastic paraplegia, HSP, SPG, Strümpell-Lorrain disease, familial spastic paraplegia, hereditary spastic paraparesis, FSP, familial spastic paraparesis

41 clinical trials for this condition and its sub-types.

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Sub-types

Spastic paraplegia, optic atropy, and neuropathy (3) Hereditary spastic paraplegia 3A (2) Hereditary spastic paraplegia 4 (2) Hereditary spastic paraplegia 50 (2) Hereditary spastic paraplegia 5A (2) Complex hereditary spastic paraplegia (1) Hereditary spastic paraplegia 11 (1) Hereditary spastic paraplegia 15 (1) Hereditary spastic paraplegia 26 (1) Hereditary spastic paraplegia 47 (1) Hereditary spastic paraplegia 51 (1) Hereditary spastic paraplegia 52 (1) Hereditary spastic paraplegia 63 (1) Hereditary spastic paraplegia 7 (1) ADAR-related hereditary spastic paraplegia (0) Autosomal dominant complex spastic paraplegia (0) Autosomal dominant complex spastic paraplegia type 9B (0) Autosomal dominant spastic paraplegia type 9 (0) Autosomal recessive complex spastic paraplegia due to kennedy pathway dysfunction (0) Autosomal recessive complex spastic paraplegia type 9B (0)

Broader categories

Disease (618) Nervous system disorder (217) Hereditary disease (172) Neurodegenerative disease (155) Neuromuscular disease (98) Central nervous system disorder (97) Paraplegia (37) Palsy (29) Human disease (14) Inherited neurodegenerative disorder (10)

Trials to join now! 16 Not yet recruiting 2 Not yet finished but already full! 9 Completed 12 Terminated 2