Hemolytic anemia
MONDO:0003664Anemia resulting from the premature destruction of the peripheral blood red cells. It may be congenital or it may be caused by infections, medications, or malignancies.
Also known as: anaemia hemolytic, anemia hemolytic, anemia, hemolytic, hemolytic anemia
188 clinical trials for this condition and its sub-types, 19 tagged with Hemolytic anemia itself.
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Sub-types of Hemolytic anemia
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Paroxysmal nocturnal hemoglobinuria 73 trials
2 sub-types
- Paroxysmal nocturnal hemoglobinuria 1 0 trials
- Paroxysmal nocturnal hemoglobinuria 2 0 trials
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Autoimmune hemolytic anemia 49 trials · 72 incl. sub-types
7 sub-types
- Autoimmune hemolytic anemia, warm type 29 trials
- Evans syndrome 19 trials
- Autoimmune hemolytic anemia, cold type 2 trials · 15 incl. sub-types Sub-types →
- Mixed-type autoimmune hemolytic anemia 1 trial
- Drug-induced autoimmune hemolytic anemia 0 trials
- Giant cell hepatitis with autoimmune hemolytic anemia 0 trials
- Neonatal autoimmune hemolytic anemia 0 trials
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Familial hemolytic anemia 4 trials · 27 incl. sub-types
23 sub-types
- Congenital nonspherocytic hemolytic anemia 1 trial · 12 incl. sub-types Sub-types →
- Congenital dyserythropoietic anemia 4 trials · 5 incl. sub-types Sub-types →
- Abetalipoproteinemia 2 trials
- Cutaneous porphyria 2 trials
- Hereditary spherocytosis 2 trials Sub-types →
- Southeast Asian ovalocytosis 2 trials
- Glycogen storage disease VII 1 trial
- Glycogen storage disease due to aldolase A deficiency 1 trial
- Rh deficiency syndrome 0 trials
- X-linked congenital hemolytic anemia 0 trials
- Cryohydrocytosis 0 trials
- Dehydrated hereditary stomatocytosis 2 0 trials
- Dehydrated hereditary stomatocytosis with or without pseudohyperkalemia and/or perinatal edema 0 trials
- Elliptocytosis 1 0 trials
- Elliptocytosis 2 0 trials
- Familial pseudohyperkalemia 0 trials
- Hemolytic anemia due to diphosphoglycerate mutase deficiency 0 trials
- Hemolytic disease of fetus and newborn, RH-induced 0 trials
- Hereditary cryohydrocytosis with reduced stomatin 0 trials
- Overhydrated hereditary stomatocytosis 0 trials
- Primary CD59 deficiency 0 trials
- Renal tubular acidosis, distal, 4, with hemolytic anemia 0 trials
- Triosephosphate isomerase deficiency 0 trials
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Hereditary stomatocytosis 1 trial · 3 incl. sub-types
7 sub-types
- Southeast Asian ovalocytosis 2 trials
- Rh deficiency syndrome 0 trials
- Cryohydrocytosis 0 trials
- Dehydrated hereditary stomatocytosis 0 trials Sub-types →
- Familial pseudohyperkalemia 0 trials
- Hereditary cryohydrocytosis with reduced stomatin 0 trials
- Overhydrated hereditary stomatocytosis 0 trials
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Hereditary elliptocytosis 0 trials · 2 incl. sub-types
5 sub-types
- Southeast Asian ovalocytosis 2 trials
- Elliptocytosis 1 0 trials
- Elliptocytosis 2 0 trials
- Elliptocytosis 3 0 trials
- Hemolytic anemia with thermal sensitivity of red cells 0 trials
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Non-autoimmune hemolytic anemia 1 trial
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Heinz body anemia 0 trials
Most studied deeper sub-types
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Turmeric gel could offer new hope for sickle cell patients
Disease control Recruiting nowThis early-stage trial is testing whether a skin gel made from curcumin (a compound in turmeric) can be safely absorbed by adults with stable sickle cell disease. Researchers will apply the gel to the forearms twice a week for six weeks and monitor for side effects. The goal is t…
Phase 1 • Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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New pill aims to ease sickle cell anemia without pain crises
Disease control Recruiting nowThis study tests a drug called SIL-8301 (senicapoc) in 105 adults with sickle cell disease who have low hemoglobin but few pain crises. Participants take the drug or a placebo daily for 24 weeks, along with their usual hydroxyurea. The main goal is to see if the drug raises hemog…
Phase 2 • Sponsor: Biossil Inc. • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New drug pegcetacoplan tested in teens with rare blood disorder
Disease control Recruiting nowThis study tests a drug called pegcetacoplan in 12 to 17-year-olds with paroxysmal nocturnal hemoglobinuria (PNH), a rare blood disorder that destroys red blood cells. The drug aims to control the disease by blocking part of the immune system. The trial will check safety, how the…
Phase 2 • Sponsor: Apellis Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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New hope for PNH patients: early access to danicopan combo therapy
Disease control Expanded accessThis program provides early access to danicopan for adults with paroxysmal nocturnal hemoglobinuria (PNH) who have significant extravascular hemolysis (EVH) despite treatment with Soliris or Ultomiris. Participants must be 18 or older, have anemia and high reticulocyte counts, an…
Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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New drug combo aims to boost red blood cells in kids with rare blood disorder
Disease control Recruiting nowThis phase 3 study tests whether adding danicopan to standard PNH medications (ravulizumab or eculizumab) can improve hemoglobin levels in children aged 12 to 17 with paroxysmal nocturnal hemoglobinuria who still have significant anemia from extravascular hemolysis. Six participa…
Phase 3 • Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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New study aims to unlock genetic secrets of red blood cell diseases
Knowledge-focused Recruiting nowThis research study is looking at people with inherited red blood cell disorders, such as hemolytic anemia, to better understand the genetic causes. Researchers will study blood samples from up to 400 participants to identify specific gene changes. The goal is to improve diagnosi…
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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X-rays may damage red blood cells: study seeks safe limits
Knowledge-focused Recruiting nowThis study looks at how X-ray irradiation used during cancer surgery affects red blood cells. Researchers will take blood from 20 patients having tumor surgery and test it with different X-ray doses. They will check for changes in cell shape, flexibility, and oxygen-carrying abil…
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC