GRIN1-related complex neurodevelopmental disorder
MONDO:1060123A neurodevelopmental disorder caused by variation in the GRIN1 gene. It is characterized by mild-to-profound developmental delay/intellectual disability (DD/ID) in all affected individuals. Other common manifestations are epilepsy, muscular hypotonia, movement disorders, spasticity, feeding difficulties, and behavior issues. A subset of individuals show a malformation of cortical development consisting of extensive and diffuse bilateral polymicrogyria.
Also known as: GRIN1-related developmental and epileptic encephalopathy, GRIN1-related neurodevelopmental disorder
24 clinical trials for this condition and its sub-types.
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Broader categories
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Can an iPad game spot autism early?
Diagnosis CompletedThis study tested whether an iPad game (Play.Care) could help diagnose autism spectrum disorder (ASD) in children aged 2.5 to 5 years. The game measures how children move while playing, since movement differences may be early signs of autism. Researchers compared the game's resul…
Phase: NA • Sponsor: University of Strathclyde • Aim: Diagnosis
Last updated Jun 27, 2026 12:09 UTC
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New parent support programme shows promise for families of children with complex needs
Symptom relief CompletedThis pilot study tested a community-based group programme called 'Encompass' for parents of children under 5 with complex neurodisability. Fifteen parents in East London attended ten group sessions over six months. The study aimed to see if the programme was feasible and acceptab…
Phase: NA • Sponsor: City, University of London • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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New program aims to help siblings of chronically ill children
Symptom relief CompletedThis completed trial tested a 5-session group program for siblings and parents of children with chronic illness. The goal was to improve sibling mental health, family communication, and quality of life. 288 families participated, with some receiving the program immediately and ot…
Phase: NA • Sponsor: University of Oslo • Aim: Symptom relief
Last updated Jun 26, 2026 18:43 UTC
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Could hidden nerve damage explain pain in kids with developmental delays?
Knowledge-focused CompletedThis completed study looked at whether children with neurodevelopmental disorders (like mitochondrial disease, cerebral palsy, or developmental delay) have fewer small nerve fibers in their skin, which could cause pain. Researchers took small skin biopsies from 203 children—some …
Sponsor: Heinrich-Heine University, Duesseldorf • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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New screening tool aims to spot suicide risk in kids with autism
Knowledge-focused CompletedThis study tested a set of questions to better identify suicide risk in young people aged 8–17 with autism or other neurodevelopmental disorders. Researchers asked 278 participants and their parents about thoughts of self-harm and understanding of death. The goal was to create a …
Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC