Functional colonic disease

This completed trial tested whether a mix of 43 plant polyphenols can counteract health damage from environmental pollutants. 98 adults took either the polyphenol supplement or a placebo for a period. Researchers measured changes in gut health, inflammation, and blood markers to …

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether a probiotic called Lactobacillus rhamnosus GG can reduce inflammation and PTSD symptoms in veterans. Researchers enrolled 383 veterans with PTSD and gut issues, giving them either the probiotic or a placebo. The goal was to see if calming inflammation in…

This study tested if listening to hypnotherapy audio files can help children and teens with stomach pain and bowel problems linked to stress. 32 participants used the audio treatment at home. The goal was to see if this approach is practical and effective, potentially offering a …

This pilot study tested whether a guided imagery therapy mobile app could help children aged 7 to 12 with chronic abdominal pain. Four children listened to 10-15 minute recorded sessions five days a week for eight weeks. The study compared immediate app use to a delayed start gro…

This study tested a new diet called 5Ad against the well-known low FODMAP diet in 52 adults with ongoing stomach issues like bloating, pain, and irregular bowel movements. Each person tried both diets for a week, with a break in between. The goal was to see if the 5Ad diet works …

This study tested a fixed-dose combination of Mebeverine (a muscle relaxant) and Simethicone (a gas reducer) against each drug alone in 465 adults with functional bowel disorders causing abdominal pain and bloating. The goal was to see if the combo pill better reduces pain and bl…

This study looked at how well people with self-reported fiber sensitivity tolerate different doses of soluble fiber. 141 adults took fiber or a placebo for 7 days, and researchers measured digestive symptoms and dropout rates. The goal was to find a dose that causes minimal disco…

This study looked at whether magnetic stimulation of nerves in the lower back can change how the colon moves. It included 30 people: healthy volunteers, and patients with constipation or fecal incontinence. The goal was to understand the effect, not to treat the condition.

This study looked at 163 children aged 7-12 with chronic abdominal pain to see if simple tests (biomarkers) could predict whether they would benefit more from cognitive behavioral therapy (CBT) or a low FODMAP diet. The goal was to personalize treatment and improve symptoms and q…