New combo pill targets tummy troubles: pain and gas relief in one

NCT ID NCT05175131

Completed Symptom relief Sponsor: Abbott Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a fixed-dose combination of Mebeverine (a muscle relaxant) and Simethicone (a gas reducer) against each drug alone in 465 adults with functional bowel disorders causing abdominal pain and bloating. The goal was to see if the combo pill better reduces pain and bloating after 4 weeks. Participants rated their symptoms daily on a 0-10 scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Mebeverine + Simethicone fixed-dose combination
What this could lead to: If successful, this combination pill could offer a more convenient and effective way to relieve both abdominal pain and bloating in people with functional bowel disorders.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The combination may not prove significantly better than taking either drug alone, and individual responses vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Abdominal Pain Flatulence functional colonic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FUNCTIONAL BOWEL DISORDER

Contacts and locations

Locations

Null Research Facilities

Moscow, Russia

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