Friedreich ataxia
MONDO:0100339An inherited condition that affects the nervous system and causes movement problems. People with this condition develop impaired muscle coordination (ataxia) that worsens over time. Other features include the gradual loss of strength and sensation in the arms and legs, muscle stiffness (spasticity), and impaired speech. Many individuals have a form of heart disease called hypertrophic cardiomyopathy. Some develop diabetes, impaired vision, hearing loss, or an abnormal curvature of the spine (scoliosis). Most people with Friedreich ataxia begin to experience the signs and symptoms around puberty.
Also known as: FA, FRDA, Friedreich ataxia, Friedreich's Ataxia, Friedreich's ataxia, Friedreich ataxia with retained reflexes, hereditary spinal ataxia, hereditary spinal sclerosis
58 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
-
Experimental drug aims to halt rare neurological decline
Disease control Not yet recruitingThis Phase 3 trial tests whether vatiquinone can slow the progression of Friedreich's ataxia, a rare genetic disorder that damages the nervous system and impairs movement. About 120 adults with moderate symptoms will take the drug for 24 months. Researchers will measure changes i…
Phase: PHASE3 • Sponsor: PTC Therapeutics • Aim: Disease control
Last updated Jul 04, 2026 00:00 UTC
-
Can intense walking training help brain injury patients walk better?
Symptom relief Not yet recruitingThis study looks at whether high-intensity walking training can help people with cerebellar damage (a part of the brain that controls balance and coordination) improve their walking ability. Twenty participants will either do intense walking exercises or standard training. The go…
Phase: NA • Sponsor: Indiana University • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
-
Could a zapping cap boost memory? small study tests brain stimulation for cognitive decline
Symptom relief Not yet recruitingThis pilot study will test whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive low-level electrica…
Phase: NA • Sponsor: Sunnybrook Health Sciences Centre • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
-
Exercise and drug combo may fight fatigue in rare disease
Symptom relief Not yet recruitingThis study looks at whether doing aerobic exercise at home, with or without the drug omaveloxolone, can safely improve fatigue and heart-lung fitness in people with Friedreich's ataxia. About 30 adults with the condition will take part. The goal is to see if the combination helps…
Phase: NA • Sponsor: Scott Barbuto • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
-
AI vs. experts: can a computer judge speech as well as a human?
Knowledge-focused Not yet recruitingThis study will compare how well an AI program (Blings) measures speech clarity in 40 adults with speech disorders from stroke or other neurological conditions. Two speech therapists will also rate the same speech samples. The goal is to see if the AI can reliably replace or assi…
Sponsor: Pusan National University Yangsan Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC