Fragile X syndrome
MONDO:0010383A genetic syndrome caused by mutations in the FMR1 gene which is responsible for the expression of the fragile X mental retardation 1 protein. This protein participates in neural development. This syndrome is manifested with mental, emotional, behavioral, physical, and learning disabilities.
Also known as: FRAXA syndrome, FXS, FraX syndrome, Fragile X syndrome, X-linked dominant, Martin-Bell syndrome, fragile X intellectual disability syndrome, fragile X syndrome, marker X syndrome
34 clinical trials for this condition and its sub-types.
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Broader categories
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New drug SPG601 aims to boost brain function in fragile x patients
Symptom relief Not yet recruitingThis study tests a new drug called SPG601 in adult men with Fragile X syndrome. The goal is to see if it can improve thinking and brain function. About 248 participants will receive either the drug or a placebo. The study is not yet recruiting.
Phase 2/3 • Sponsor: Spinogenix • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Could a pill tame aggression in fragile x? new trial aims to find out
Symptom relief Not yet recruitingThis study tests whether the drug SRX246 can reduce irritability, aggression, and self-injury in adult males with Fragile X syndrome. Eighty participants will take either SRX246 or a placebo daily for up to 8 months, with regular check-ins by phone or home visits. The goal is to …
Phase 2 • Sponsor: Azevan Pharmaceuticals • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC