Filariasis
MONDO:0016075A parasitic disease caused by tissue-invasive, vector-borne nematodes which can be found anywhere in the human body and that are transmitted to humans through the bite of an infected mosquito or fly or by consumption of unsafe drinking water and which, depending on the subtype can manifest with lymphedema, dermatitis, subcutaneous edema and eye involvement. The disorder is a major public health problem in many tropical and subtropical countries. Six subtypes have been described in the literature: lymphatic filariasis, onchocerciasis, loiasis, mansonelliasis, dirofilariasis and dracunculiasis caused by Wuchereria bancrofti and filarioidea of the genus Brugia; Onchocerca volvulus; Loa loa; Mansonella; Dirofilaria; and Dracunculus medinensis, respectively. Tropical eosinophilia is considered a frequent manifestation.
16 clinical trials for this condition and its sub-types, 10 tagged with Filariasis itself.
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Sub-types of Filariasis
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Filarial elephantiasis 9 trials
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Onchocerciasis 9 trials
1 sub-type
- Ocular onchocerciasis 2 trials
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Loiasis 2 trials
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Mansonelliasis 1 trial
1 sub-type
- Mansonella ozzardi infection 0 trials
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Dirofilariasis 0 trials
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Dracunculiasis 0 trials
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Setariasis 0 trials
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Could a new drug combo beat elephantiasis?
Disease control CompletedThis study tested whether a drug called moxidectin, combined with other medicines, works better than the standard treatment (ivermectin combinations) for lymphatic filariasis, a parasitic disease that can cause severe swelling. 164 adults with the infection received a single dose…
Phase 3 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Mass deworming experiment aims to wipe out parasitic worms in three countries
Disease control CompletedThis massive study tested whether giving deworming medicine (albendazole) to everyone in a community, not just children, can break the cycle of soil-transmitted worm infections. Over 350,000 people in India, Malawi, and Benin took part. The goal was to see if treating entire vill…
Phase 3 • Sponsor: University of Washington • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Can we unmask the hidden interference in filariasis testing?
Knowledge-focused CompletedThis study investigates why people with loiasis, a parasitic infection, may test positive on rapid diagnostic tests for lymphatic filariasis. Researchers will follow 60 individuals with high loiasis worm burdens to monitor the release of filarial antigens in their blood. By ident…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC